Cofactor replacement therapy

This page covers all Cofactor replacement therapy drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Phenylalanine ammonia-lyase (PAL) enzyme cofactor, Phenylalanine ammonia-lyase (PAL) cofactor.

Targets

Phenylalanine ammonia-lyase (PAL) enzyme cofactor · Phenylalanine ammonia-lyase (PAL) cofactor

Marketed (2)

• Kuvan® · Merck KGaA, Darmstadt, Germany · Metabolic/Genetic Disorders
  Kuvan is a synthetic form of tetrahydrofolate (BH4) that acts as a cofactor to restore phenylalanine ammonia-lyase (PAL) enzyme activity, enabling the metabolism of phenylalanine in patients with phenylketonuria.
• saproterin dihydrochloride · University Hospitals Cleveland Medical Center · Metabolic/Genetic Disorder
  Saproterin dihydrochloride is a synthetic form of tetrahydrofolate that acts as a cofactor to enhance phenylalanine ammonia-lyase (PAL) enzyme activity, reducing blood phenylalanine levels in phenylketonuria.