CFTR modulator combination

This page covers all CFTR modulator combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), CFTR (cystic fibrosis transmembrane conductance regulator).

Targets

CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) · CFTR (cystic fibrosis transmembrane conductance regulator)

Marketed (1)

• Ivacaftor/Ataluren · University of Alabama at Birmingham · Respiratory / Genetic Disorders
  This combination therapy enhances defective CFTR protein function through two complementary mechanisms: ivacaftor acts as a CFTR potentiator to increase channel opening, while ataluren promotes read-through of nonsense mutations to restore full-length CFTR protein production.

Phase 3 pipeline (1)

• ELX/TEZ/IVA · Vertex Pharmaceuticals Incorporated · Respiratory / Genetic Disease
  ELX/TEZ/IVA is a triple combination of CFTR modulators that work together to restore function of the cystic fibrosis transmembrane conductance regulator protein.