What are CFTR modulator drugs?

CFTR modulator drugs are pharmacologic agents that share a common mechanism (typically targeting CFTR (cystic fibrosis transmembrane conductance regulator)). 1 are currently marketed, with 7 more in clinical development.

What are the marketed CFTR modulator drugs?

Marketed CFTR modulator drugs include Initiation of CFTR Modulator.

CFTR modulator

1 marketed 5 in Phase 3 2 in Phase 2

This page covers all CFTR modulator drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting CFTR (cystic fibrosis transmembrane conductance regulator), CFTR.

Targets

CFTR (cystic fibrosis transmembrane conductance regulator) · CFTR

Marketed (1)

Initiation of CFTR Modulator · Children's Hospital Medical Center, Cincinnati · Pulmonary/Genetic
CFTR modulators restore function to the cystic fibrosis transmembrane conductance regulator (CFTR) protein, improving chloride ion transport across cell membranes.

Phase 3 pipeline (5)

VX-445/TEZ/IVA · Vertex Pharmaceuticals Incorporated · Pulmonology
VX-445/TEZ/IVA is a combination of three cystic fibrosis transmembrane conductance regulator (CFTR) modulators.
TEZ/IVA · Vertex Pharmaceuticals Incorporated · Pulmonology
TEZ/IVA is a combination of tezacaftor and ivacaftor, which work together to increase the function of the CFTR protein in the lungs.
VNZ/TEZ/D-IVA · Vertex Pharmaceuticals Incorporated · Cystic Fibrosis
VNZ/TEZ/D-IVA is a triple combination therapy consisting of a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, a corrector, and a potentiator.
VX-661 plus ivacaftor combination · Vertex Pharmaceuticals Incorporated · Respiratory
VX-661 is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector, and ivacaftor is a CFTR potentiator.
VX-121/TEZ/D-IVA · Vertex Pharmaceuticals Incorporated · Pulmonology
VX-121/TEZ/D-IVA is a triple combination of a cystic fibrosis transmembrane conductance regulator (CFTR) corrector (VX-121), a CFTR potentiator (tezacaftor), and a CFTR amplifier (ivacaftor).

Phase 2 pipeline (2)

CHF 1535 Next DPI · Chiesi Farmaceutici S.p.A. · Respiratory
CHF 1535 Next DPI is a dry powder inhaler for the treatment of cystic fibrosis.
CFTR modulators · Hospices Civils de Lyon · Respiratory
CFTR modulators work by modifying the cystic fibrosis transmembrane conductance regulator protein to restore normal chloride ion transport across epithelial cell membranes.