What are CFTR corrector drugs?

CFTR corrector drugs are pharmacologic agents that share a common mechanism (typically targeting CFTR (cystic fibrosis transmembrane conductance regulator)). 1 are currently marketed, with 4 more in clinical development.

What are the marketed CFTR corrector drugs?

Marketed CFTR corrector drugs include TEZ.

CFTR corrector

1 marketed 3 in Phase 3 1 in Phase 2

This page covers all CFTR corrector drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting CFTR (cystic fibrosis transmembrane conductance regulator), CFTR.

Targets

CFTR (cystic fibrosis transmembrane conductance regulator) · CFTR

Marketed (1)

TEZ · Vertex Pharmaceuticals Incorporated · Pulmonary/Genetic Disorders
TEZ (tezacaftor) is a CFTR corrector that helps misfolded cystic fibrosis transmembrane conductance regulator (CFTR) protein fold correctly and traffic to the cell surface.

Phase 3 pipeline (3)

ARINA-1 · Renovion, Inc. · Respiratory
ARINA-1 is a small molecule inhaled cystic fibrosis transmembrane conductance regulator (CFTR) corrector.
VX-809 · Vertex Pharmaceuticals Incorporated · Cystic Fibrosis
VX-809 is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.
VX-661/Ivacaftor · Vertex Pharmaceuticals Incorporated · Respiratory
VX-661/Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.

Phase 2 pipeline (1)

CHF5633 · Chiesi Farmaceutici S.p.A. · Respiratory
CHF5633 is a small molecule in development for the treatment of cystic fibrosis.