What are Calcimimetic agent drugs?

Calcimimetic agent drugs are pharmacologic agents that share a common mechanism (typically targeting Calcium-sensing receptor (CaSR)). 1 are currently marketed, with 2 more in clinical development.

What are the marketed Calcimimetic agent drugs?

Marketed Calcimimetic agent drugs include AMG 073.

Calcimimetic agent

1 marketed 1 in Phase 3 1 in Phase 2

This page covers all Calcimimetic agent drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Calcium-sensing receptor (CaSR).

Targets

Calcium-sensing receptor (CaSR)

Marketed (1)

AMG 073 · Amgen · Endocrinology / Nephrology
AMG 073 is a calcimimetic agent that allosterically activates the calcium-sensing receptor on the parathyroid gland, increasing its sensitivity to extracellular calcium and thereby suppressing parathyroid hormone secretion.

Phase 3 pipeline (1)

Experimental: SNF472 · Sanifit Therapeutics S. A. · Nephrology / Cardiovascular
SNF472 is a calcimimetic agent that binds to and activates the calcium-sensing receptor to reduce serum phosphate levels in patients with chronic kidney disease.

Phase 2 pipeline (1)

AMT-676 · Multitude Therapeutics Inc. · Nephrology / Endocrinology
AMT-676 is a small-molecule allosteric modulator of the calcium-sensing receptor (CaSR) that enhances receptor sensitivity to extracellular calcium.