Beta-lactam antibiotic combination

This page covers all Beta-lactam antibiotic combination drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Penicillin-binding proteins (PBPs); bacterial cell wall peptidoglycan, Bacterial penicillin-binding proteins (PBPs); beta-lactamase inhibition, Penicillin-binding proteins (PBPs).

Targets

Penicillin-binding proteins (PBPs); bacterial cell wall peptidoglycan · Bacterial penicillin-binding proteins (PBPs); beta-lactamase inhibition · Penicillin-binding proteins (PBPs) · Bacterial cell wall synthesis (MurA enzyme and penicillin-binding proteins) · Penicillin-binding proteins (PBPs); bacterial cell wall

Marketed (4)

• Pivmecillinam/augmentin · Radboud University Medical Center · Infectious Disease
  Pivmecillinam is a beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, while augmentin (amoxicillin/clavulanic acid) combines a beta-lactam with a beta-lactamase inhibitor to overcome resistance.
• Ceftolozane-tazobactam + Meropenem · National University of Singapore · Infectious Disease
  This combination inhibits bacterial cell wall synthesis through dual beta-lactam action (ceftolozane-tazobactam and meropenem) while tazobactam protects against beta-lactamase resistance.
• ceftriaxone/oxacillin · UPECLIN HC FM Botucatu Unesp · Infectious Disease
  This combination of two beta-lactam antibiotics inhibits bacterial cell wall synthesis through inhibition of penicillin-binding proteins, providing broad-spectrum coverage against gram-positive and gram-negative bacteria.
• Fosfomycin and imipenem · Juan A. Arnaiz · Infectious Disease
  Fosfomycin and imipenem together provide dual antibiotic action by inhibiting bacterial cell wall synthesis through different mechanisms to treat serious infections.

Phase 3 pipeline (1)

• Cefazolin, Bacitracin, Cefalexin · Population Health Research Institute · Infectious Disease
  This is a combination of three beta-lactam antibiotics that inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins.