What are Antimetabolite chemotherapy drugs?

Antimetabolite chemotherapy drugs are pharmacologic agents that share a common mechanism (typically targeting Thymidylate synthase). 0 are currently marketed, with 3 more in clinical development.

Antimetabolite chemotherapy

0 marketed 3 in Phase 3

This page covers all Antimetabolite chemotherapy drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Thymidylate synthase, Thymidylate synthase; DNA/RNA incorporation.

Targets

Thymidylate synthase · Thymidylate synthase; DNA/RNA incorporation

Phase 3 pipeline (3)

UFT adjuvant chemotherapy · Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan · Oncology
UFT is a combination of uracil and tegafur (a prodrug of fluorouracil) that inhibits thymidylate synthase to disrupt DNA synthesis in cancer cells.
Placebo、5-Fluorouracil、Leucovorin · Jiangsu HengRui Medicine Co., Ltd. · Oncology
5-Fluorouracil is a pyrimidine antimetabolite that inhibits thymidylate synthase and gets incorporated into RNA, disrupting nucleotide synthesis and cancer cell division, while leucovorin enhances its efficacy by stabilizing the drug-enzyme complex.
Fluoropyrimidine-based Chemotherapy · Hoffmann-La Roche · Oncology
Fluoropyrimidine-based chemotherapy inhibits thymidylate synthase and incorporates into DNA/RNA to disrupt cancer cell replication and survival.