Antimalarial agent; 4-aminoquinoline

This page covers all Antimalarial agent; 4-aminoquinoline drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Heme; Toll-like receptors (secondary immunomodulatory effects), Heme; Toll-like receptors (immunomodulatory effects), Parasite heme polymerase (CQ); hypnozoite mitochondrial electron transport (PQ).

Targets

Heme; Toll-like receptors (secondary immunomodulatory effects) · Heme; Toll-like receptors (immunomodulatory effects) · Parasite heme polymerase (CQ); hypnozoite mitochondrial electron transport (PQ)

Marketed (2)

• Chloroquine diphosphate · University of Sao Paulo General Hospital · Infectious Disease; Immunology
  Chloroquine diphosphate is an antimalarial agent that accumulates in parasitic food vacuoles and inhibits heme polymerization, leading to parasite death.
• Chloroquine Sulfate · Washington University School of Medicine · Infectious Disease; Rheumatology (off-label)
  Chloroquine sulfate is an antimalarial agent that accumulates in parasitic food vacuoles and inhibits heme polymerization, leading to parasite death.

Phase 3 pipeline (1)

• CQ and PQ starting on Day 42 · Fundação de Medicina Tropical Dr. Heitor Vieira Dourado · Infectious Disease
  CQ (chloroquine) and PQ (primaquine) are antimalarial agents that inhibit parasite DNA replication and metabolism, with PQ also targeting hypnozoites to prevent relapse.

Patent intelligence

• antimalarial agent patent landscape — aggregated cliff calendar, attackable patents, originator estates