Antifolate antimetabolite

This page covers all Antifolate antimetabolite drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formyltransferase, Dihydrofolate reductase (DHFR), folate receptor, reduced folate carrier.

Targets

Thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formyltransferase · Dihydrofolate reductase (DHFR), folate receptor, reduced folate carrier

Marketed (2)

• Pemetrexed + oral folinic acid rescue · Radboud University Medical Center · Oncology
  Pemetrexed inhibits multiple folate-dependent enzymes involved in nucleotide synthesis, and oral folinic acid rescue protects normal cells from toxicity while allowing cancer cell death.
• Intrathecal injection of pemetrexed · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Oncology
  Pemetrexed inhibits multiple folate-dependent enzymes involved in nucleotide synthesis, disrupting DNA and RNA production in cancer cells when delivered directly into the cerebrospinal fluid.

Phase 3 pipeline (5)

• Pralatrexate injection · Mundipharma K.K. · Oncology
  Pralatrexate is a folate analog that inhibits dihydrofolate reductase and other folate-dependent enzymes, disrupting DNA synthesis and cell division in rapidly dividing cells.
• Pemetrexed therapy · The First Affiliated Hospital with Nanjing Medical University · Oncology
  Pemetrexed inhibits multiple folate-dependent enzymes involved in nucleotide synthesis, disrupting DNA and RNA production in cancer cells.
• Pemetrexed Disodium Injection · Shanghai Miracogen Inc. · Oncology
  Pemetrexed is a folate antagonist that inhibits multiple enzymes involved in nucleotide synthesis, disrupting DNA and RNA production in cancer cells.
• Pemetrexed Disodium for Injection · Allist Pharmaceuticals, Inc. · Oncology
  Pemetrexed is a folate antagonist that inhibits multiple enzymes involved in nucleotide synthesis, disrupting DNA and RNA production in cancer cells.
• Pemetrexed disodium f Injection · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · Oncology
  Pemetrexed is a folate antagonist that inhibits multiple enzymes involved in nucleotide synthesis, disrupting DNA and RNA production in cancer cells.