Antifolate antimalarial

This page covers all Antifolate antimalarial drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Dihydrofolate reductase; dihydropteroate synthase.

Targets

Dihydrofolate reductase; dihydropteroate synthase

Marketed (3)

• Sulfadoxine pyrimethamine · Radboud University Medical Center · Infectious Disease
  Sulfadoxine-pyrimethamine is a fixed-dose combination of two antifolate drugs that inhibits dihydrofolate reductase and dihydropteroate synthase, blocking folate synthesis in parasites and preventing malaria and toxoplasmosis.
• Sulphadoxine-Pyrimethamine · ORIYOMI OMOTOYOSI AKINYOTU · Infectious Disease
  Sulphadoxine-pyrimethamine inhibits dihydrofolate reductase and dihydropteroate synthase in parasites, blocking folate synthesis and DNA replication.
• Sulfadoxine-pyrimethamine/folic acid · Centers for Disease Control and Prevention · Infectious Disease
  Sulfadoxine-pyrimethamine inhibits dihydrofolate reductase and dihydropteroate synthase in parasites, blocking folate synthesis, while folic acid supplementation protects human cells from toxicity.