What are Anthracycline topoisomerase II inhibitor drugs?

Anthracycline topoisomerase II inhibitor drugs are pharmacologic agents that share a common mechanism (typically targeting Topoisomerase II, DNA). 2 are currently marketed, with 5 more in clinical development.

What are the marketed Anthracycline topoisomerase II inhibitor drugs?

Marketed Anthracycline topoisomerase II inhibitor drugs include Epirubicin (E), Idarubicin(IDA).

Anthracycline topoisomerase II inhibitor

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

2 marketed 5 in Phase 3

This page covers all Anthracycline topoisomerase II inhibitor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Topoisomerase II, DNA, Topoisomerase II; DNA.

Targets

Topoisomerase II, DNA · Topoisomerase II; DNA

Marketed (2)

Epirubicin (E) · Eye & ENT Hospital of Fudan University · Oncology
Epirubicin is a topoisomerase II inhibitor that intercalates into DNA and prevents cancer cell replication and survival.
Idarubicin(IDA) · Chinese Academy of Medical Sciences · Oncology
Idarubicin is a topoisomerase II inhibitor that intercalates into DNA and prevents DNA unwinding, leading to cell death in rapidly dividing cancer cells.

Phase 3 pipeline (5)

Daunorubicin or Idarubicin · Stichting Hemato-Oncologie voor Volwassenen Nederland · Oncology
Daunorubicin and idarubicin are anthracycline chemotherapy agents that intercalate into DNA and inhibit topoisomerase II, leading to DNA damage and cancer cell death.
Epirubicin Hydrochloride for Injection · Suzhou Suncadia Biopharmaceuticals Co., Ltd. · Oncology
Epirubicin intercalates into DNA and inhibits topoisomerase II, leading to DNA damage and cell death in rapidly dividing cancer cells.
Hign dose Daunorubicin · Asan Medical Center · Oncology
High-dose daunorubicin is a topoisomerase II inhibitor anthracycline that intercalates into DNA and prevents cell division, primarily used in hematologic malignancies.
Epirubicin Injectable Product · The First Affiliated Hospital with Nanjing Medical University · Oncology
Epirubicin is a topoisomerase II inhibitor that intercalates into DNA and prevents DNA unwinding, leading to cell death in rapidly dividing cancer cells.
Doxorubicin (A) · Merck Sharp & Dohme LLC · Oncology
Doxorubicin intercalates into DNA and inhibits topoisomerase II, preventing DNA replication and transcription in cancer cells.

Patent intelligence

anthracycline topoisomerase ii inhibitor patent landscape — aggregated cliff calendar, attackable patents, originator estates