8-aminoquinoline antimalarial

This page covers all 8-aminoquinoline antimalarial drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Plasmodium mitochondrial electron transport chain, Plasmodium hypnozoites (mechanism not fully elucidated at molecular level), Malaria parasite mitochondria and DNA (indirect via oxidative stress).

Targets

Plasmodium mitochondrial electron transport chain · Plasmodium hypnozoites (mechanism not fully elucidated at molecular level) · Malaria parasite mitochondria and DNA (indirect via oxidative stress) · Plasmodium parasite mitochondria and DNA · Plasmodium hypnozoite mitochondria · Malaria parasite (Plasmodium spp.) — mechanism involves oxidative stress generation · Plasmodium hypnozoite (liver stage parasite)

Marketed (5)

• Tafenoquine prophylaxis · Naval Medical Research Center · Infectious Disease
  Tafenoquine is an 8-aminoquinoline that kills malaria parasites by generating reactive oxygen species in the parasite mitochondria.
• PQ supervised · Menzies School of Health Research · Infectious Disease / Parasitology
  PQ supervised is a directly observed therapy (DOT) program for primaquine administration in malaria treatment.
• Unsupervised primaquine treatment · Menzies School of Health Research · Infectious Disease
  Primaquine is an 8-aminoquinoline antimalarial that eliminates malaria parasites by generating reactive oxygen species that damage parasite DNA and mitochondria.
• Supervised primaquine treatment · Menzies School of Health Research · Infectious Disease
  Primaquine is an 8-aminoquinoline antimalarial that eliminates malaria parasites by generating reactive oxygen species that damage parasite DNA and mitochondria.
• PQ unsupervised · Menzies School of Health Research · Infectious Disease
  PQ unsupervised is a primaquine-based antimalarial that eliminates dormant liver stages (hypnozoites) of Plasmodium vivax and P. ovale malaria parasites.

Phase 3 pipeline (3)

• High dose ultra short Primaquine · Menzies School of Health Research · Infectious Disease
  High-dose ultra-short primaquine rapidly eliminates malaria parasites, particularly gametocytes, to prevent transmission and treat infection.
• PQ (0.75) · London School of Hygiene and Tropical Medicine · Infectious Disease / Parasitology
  PQ is a primaquine analog that acts as an 8-aminoquinoline antimalarial targeting the hypnozoite stage of Plasmodium parasites in the liver.
• PQ (0.2) · London School of Hygiene and Tropical Medicine · Infectious Disease / Parasitology
  PQ is a primaquine analog that acts as an 8-aminoquinoline antimalarial targeting the hypnozoite stage of Plasmodium vivax and P. ovale parasites.

Patent intelligence

• 8 aminoquinoline antimalarial patent landscape — aggregated cliff calendar, attackable patents, originator estates