Who are Vemurafenib (VEM)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): REGORAFENIB, vemurafenib + HD IL-2, Tunlametinib plus Vemurafenib, GSK2118436, Encorafenib and Binimetinib.

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Last reviewed 2026-06-10 · How we verify

Vemurafenib (VEM) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Vemurafenib (VEM) (Vemurafenib (VEM)) competitive landscape: 5 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: BRAF inhibitor. Area: Oncology.

marketed BRAF inhibitor BRAF V600E Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Vemurafenib (VEM) (Vemurafenib (VEM)) — Abramson Cancer Center at Penn Medicine. Vemurafenib is a small-molecule inhibitor that selectively blocks the BRAF V600E kinase mutation found in melanoma and other cancers.

Comparator set (5 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Vemurafenib (VEM) TARGET	Vemurafenib (VEM)	Abramson Cancer Center at Penn Medicine	marketed	BRAF inhibitor	BRAF V600E
REGORAFENIB	REGORAFENIB		marketed		RET, VEGFR1, VEGFR2, VEGFR3, KIT, PDGFR-alpha, PDGFR-beta, FGFR1, FGFR2, TIE2, DDR2, TrkA, Eph2A, RAF-1, BRAF, BRAF V600E, SAPK2, PTK5, Abl, CSF1R	2012-01-01
vemurafenib + HD IL-2	vemurafenib + HD IL-2	Clinigen, Inc.	marketed	BRAF inhibitor + cytokine immunotherapy	BRAF V600E kinase; IL-2 receptor
Tunlametinib plus Vemurafenib	Tunlametinib plus Vemurafenib	Shanghai Kechow Pharma, Inc.	phase 3	BRAF inhibitor + MEK inhibitor combination	BRAF V600E and MEK1/2
GSK2118436	GSK2118436	M.D. Anderson Cancer Center	phase 3	BRAF inhibitor	BRAF V600E
Encorafenib and Binimetinib	Encorafenib and Binimetinib	Pierre Fabre Medicament	phase 3	BRAF inhibitor + MEK inhibitor combination	BRAF V600E/K and MEK1/2

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (BRAF inhibitor class)

Abramson Cancer Center at Penn Medicine · 1 drug in this class
M.D. Anderson Cancer Center · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Vemurafenib (VEM) — Competitive Intelligence Brief. https://druglandscape.com/ci/vemurafenib-vem. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing