Who are Upadacitinib (ABT-494)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Leqselvi, Cibinqo, Cibinqo, ABROCITINIB, Jyseleca, Tofacitinib tablet.

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Last reviewed 2026-05-16 · How we verify

Upadacitinib (ABT-494) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Upadacitinib (ABT-494) (Upadacitinib (ABT-494)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: JAK inhibitor. Area: Immunology.

phase 3 JAK inhibitor JAK1 Immunology Small molecule Live · refreshed every 30 min

Target snapshot

Upadacitinib (ABT-494) (Upadacitinib (ABT-494)) — AbbVie. Upadacitinib is a Janus kinase (JAK) inhibitor that blocks the activity of JAK enzymes, which play a key role in the inflammatory response.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Upadacitinib (ABT-494) TARGET	Upadacitinib (ABT-494)	AbbVie	phase 3	JAK inhibitor	JAK1
Leqselvi	DEURUXOLITINIB	Sun Pharm Inds Inc	marketed		JAK1, JAK2, TYK2	2024-01-01
Cibinqo	abrocitinib	Pfizer	marketed	Janus Kinase Inhibitor [EPC]	Tyrosine-protein kinase JAK1	2022-01-01
Cibinqo	Abrocitinib	Pfizer	marketed	Janus Kinase Inhibitor [EPC]	Tyrosine-protein kinase JAK1	2022-01-01
ABROCITINIB	ABROCITINIB		marketed	Janus Kinase Inhibitor [EPC]	JAK1	2021-01-01
Jyseleca	FILGOTINIB	Gilead Sciences Ireland UC	marketed		Tyrosine-protein kinase JAK1	2020-01-01
Tofacitinib tablet	Tofacitinib tablet	Shanghai Zhongshan Hospital	marketed	JAK inhibitor	JAK1, JAK3

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (JAK inhibitor class)

Pfizer · 19 drugs in this class
Aclaris Therapeutics, Inc. · 2 drugs in this class
Beijing Friendship Hospital · 2 drugs in this class
Azienda Ospedaliero, Universitaria Pisana · 1 drug in this class
CAGE Bio Inc. · 1 drug in this class
CTI BioPharma · 1 drug in this class
Celgene · 1 drug in this class
Fred Hutchinson Cancer Center · 1 drug in this class
LEO Pharma · 1 drug in this class
McMaster University · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Upadacitinib (ABT-494) — Competitive Intelligence Brief. https://druglandscape.com/ci/upadacitinib-abt-494. Accessed 2026-05-16.

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