Last reviewed · How we verify
Unsupervised primaquine treatment — Competitive Intelligence Brief
marketed
8-aminoquinoline antimalarial
Malaria parasite mitochondria and DNA (indirect via oxidative stress)
Infectious Disease
Small molecule
Live · refreshed every 30 min
Target snapshot
Unsupervised primaquine treatment (Unsupervised primaquine treatment) — Menzies School of Health Research. Primaquine is an 8-aminoquinoline antimalarial that eliminates malaria parasites by generating reactive oxygen species that damage parasite DNA and mitochondria.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Unsupervised primaquine treatment TARGET | Unsupervised primaquine treatment | Menzies School of Health Research | marketed | 8-aminoquinoline antimalarial | Malaria parasite mitochondria and DNA (indirect via oxidative stress) | |
| PQ supervised | PQ supervised | Menzies School of Health Research | marketed | 8-aminoquinoline antimalarial | Plasmodium hypnozoites (mechanism not fully elucidated at molecular level) | |
| PQ unsupervised | PQ unsupervised | Menzies School of Health Research | marketed | 8-aminoquinoline antimalarial | Plasmodium hypnozoite mitochondria | |
| Supervised primaquine treatment | Supervised primaquine treatment | Menzies School of Health Research | marketed | 8-aminoquinoline antimalarial | Plasmodium parasite mitochondria and DNA | |
| Tafenoquine prophylaxis | Tafenoquine prophylaxis | Naval Medical Research Center | marketed | 8-aminoquinoline antimalarial | Plasmodium mitochondrial electron transport chain | |
| PQ (0.2) | PQ (0.2) | London School of Hygiene and Tropical Medicine | phase 3 | 8-aminoquinoline antimalarial | Plasmodium hypnozoite (liver stage parasite) | |
| High dose ultra short Primaquine | High dose ultra short Primaquine | Menzies School of Health Research | phase 3 | 8-aminoquinoline antimalarial | Malaria parasite (Plasmodium spp.) — mechanism involves oxidative stress generation |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (8-aminoquinoline antimalarial class)
- Menzies School of Health Research · 5 drugs in this class
- London School of Hygiene and Tropical Medicine · 2 drugs in this class
- Naval Medical Research Center · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Unsupervised primaquine treatment — Competitive Intelligence Brief. https://druglandscape.com/ci/unsupervised-primaquine-treatment. Accessed 2026-05-16.
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