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UFT, Calcium Folinate — Competitive Intelligence Brief
phase 3
Antimetabolite
Thymidylate synthase
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
UFT, Calcium Folinate (UFT, Calcium Folinate) — Iwate Medical University. UFT is a prodrug that is converted into 5-fluorouracil, which inhibits thymidylate synthase, leading to DNA damage and cell death.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| UFT, Calcium Folinate TARGET | UFT, Calcium Folinate | Iwate Medical University | phase 3 | Antimetabolite | Thymidylate synthase | |
| Xeloda | capecitabine | Cheplapharm | marketed | Nucleoside Metabolic Inhibitor [EPC] | Thymidylate synthase | 1998-01-01 |
| Fudr | FLOXURIDINE | marketed | Antimetabolite [EPC] | Thymidylate synthase | 1970-01-01 | |
| Folic Acid | FOLIC ACID | Pfizer | marketed | Vitamin C [EPC] | Thymidylate synthase | 1946-01-01 |
| Trifluridine and Tipiracil | Trifluridine and Tipiracil | Amgen | marketed | Antimetabolite combination; thymidylate synthase inhibitor | Thymidylate synthase; thymidine phosphorylase | |
| Xeloda | Xeloda | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | marketed | Thymidylate synthase | ||
| Capecitabine tablets | Capecitabine tablets | UNICANCER | marketed | Fluoropyrimidine antimetabolite | Thymidylate synthase |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Antimetabolite class)
- Grupo Espanol Multidisciplinario del Cancer Digestivo · 2 drugs in this class
- NRG Oncology · 2 drugs in this class
- Bristol-Myers Squibb · 1 drug in this class
- EMD Serono Research & Development Institute, Inc. · 1 drug in this class
- GERCOR - Multidisciplinary Oncology Cooperative Group · 1 drug in this class
- Hoffmann-La Roche · 1 drug in this class
- Centre Oscar Lambret · 1 drug in this class
- Iwate Medical University · 1 drug in this class
- Janssen Research & Development, LLC · 1 drug in this class
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh · 1 drug in this class
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Cite this brief
Drug Landscape (2026). UFT, Calcium Folinate — Competitive Intelligence Brief. https://druglandscape.com/ci/uft-calcium-folinate. Accessed 2026-06-10.
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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing