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UFT adjuvant chemotherapy — Competitive Intelligence Brief
phase 3
Antimetabolite chemotherapy
Thymidylate synthase
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
UFT adjuvant chemotherapy (UFT adjuvant chemotherapy) — Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan. UFT is a combination of uracil and tegafur (a prodrug of fluorouracil) that inhibits thymidylate synthase to disrupt DNA synthesis in cancer cells.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| UFT adjuvant chemotherapy TARGET | UFT adjuvant chemotherapy | Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan | phase 3 | Antimetabolite chemotherapy | Thymidylate synthase | |
| Xeloda | capecitabine | Cheplapharm | marketed | Nucleoside Metabolic Inhibitor [EPC] | Thymidylate synthase | 1998-01-01 |
| Fudr | FLOXURIDINE | marketed | Antimetabolite [EPC] | Thymidylate synthase | 1970-01-01 | |
| Folic Acid | FOLIC ACID | Pfizer | marketed | Vitamin C [EPC] | Thymidylate synthase | 1946-01-01 |
| Erlotinib, Pemetrexed | Erlotinib, Pemetrexed | Hunan Province Tumor Hospital | marketed | EGFR tyrosine kinase inhibitor + antifolate antimetabolite | EGFR; thymidylate synthase and folate-dependent enzymes | |
| Phthalin | PHENOLPHTHALEIN | marketed | phenolphthalein | Thymidylate synthase, Thymidylate synthase | ||
| Irinotecan, 5FU, leucovorin | Irinotecan, 5FU, leucovorin | Asan Medical Center | marketed | Chemotherapy combination (topoisomerase I inhibitor + antimetabolite) | Topoisomerase I; thymidylate synthase |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Antimetabolite chemotherapy class)
- Hoffmann-La Roche · 1 drug in this class
- Jiangsu HengRui Medicine Co., Ltd. · 1 drug in this class
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan · 1 drug in this class
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Cite this brief
Drug Landscape (2026). UFT adjuvant chemotherapy — Competitive Intelligence Brief. https://druglandscape.com/ci/uft-adjuvant-chemotherapy. Accessed 2026-05-16.
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