Who are TP05's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Otezla, Apremilast (CC-10004), Crisaborole ointment, 2%, Crisaborole Vehicle, LEO 80190, SPD503 (4 mg).

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-13 · How we verify

TP05 — Competitive Intelligence Brief

TP05 (TP05) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Phosphodiesterase 4 (PDE4) inhibitor. Area: Dermatology.

phase 3 Phosphodiesterase 4 (PDE4) inhibitor PDE4 Dermatology Small molecule Live · refreshed every 30 min

Target snapshot

TP05 (TP05) — Tillotts Pharma AG. TP05 is a topical phosphodiesterase 4 (PD4) inhibitor that reduces inflammatory cytokine production in skin.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
TP05 TARGET	TP05	Tillotts Pharma AG	phase 3	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
Otezla	APREMILAST	Amgen	marketed	Phosphodiesterase 4 Inhibitor [EPC]	PDE4	2014-01-01
Apremilast (CC-10004)	Apremilast (CC-10004)	Virginia Clinical Research, Inc.	marketed	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
Crisaborole ointment, 2%	Crisaborole ointment, 2%	Pfizer	marketed	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
Crisaborole Vehicle	Crisaborole Vehicle	Pfizer	marketed	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
LEO 80190	LEO 80190	LEO Pharma	phase 3	Phosphodiesterase 4 (PDE4) inhibitor	PDE4
SPD503 (4 mg)	SPD503 (4 mg)	Shire	phase 3	Phosphodiesterase 4 (PDE4) inhibitor	PDE4

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Phosphodiesterase 4 (PDE4) inhibitor class)

Pfizer · 6 drugs in this class
Shire · 3 drugs in this class
Almirall, S.A. · 3 drugs in this class
Arcutis Biotherapeutics, Inc. · 2 drugs in this class
LEO Pharma · 2 drugs in this class
ORA, Inc. · 1 drug in this class
Tillotts Pharma AG · 1 drug in this class
AbbVie (prior sponsor, Abbott) · 1 drug in this class
Virginia Clinical Research, Inc. · 1 drug in this class
Alfasigma S.p.A. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). TP05 — Competitive Intelligence Brief. https://druglandscape.com/ci/tp05. Accessed 2026-05-13.

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