Who are TNKase's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Oral lumbrokinase DLBS1033, Reteplase 10 U, Tenecteplase thrombolysis, reteplase 10+10 U, Intra-Arterial TNK and Albumin, thrombolysis therapy.

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Last reviewed 2026-05-14 · How we verify

TNKase — Competitive Intelligence Brief

TNKase (TNKase) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Fibrinolytic agent; tissue plasminogen activator (tPA). Area: Cardiovascular.

marketed Fibrinolytic agent; tissue plasminogen activator (tPA) Fibrin; plasminogen Cardiovascular Small molecule Live · refreshed every 30 min

Target snapshot

TNKase (TNKase) — Cedars-Sinai Medical Center. TNKase is a tissue plasminogen activator (tPA) that converts plasminogen to plasmin, which breaks down fibrin clots to restore blood flow in acute myocardial infarction.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
TNKase TARGET	TNKase	Cedars-Sinai Medical Center	marketed	Fibrinolytic agent; tissue plasminogen activator (tPA)	Fibrin; plasminogen
Oral lumbrokinase DLBS1033	Oral lumbrokinase DLBS1033	Universitas Sebelas Maret	marketed	Fibrinolytic enzyme	Fibrin; plasminogen activation pathway
Reteplase 10 U	Reteplase 10 U	The University of Texas Health Science Center, Houston	marketed	Fibrinolytic agent; tissue plasminogen activator (tPA)	Fibrin; plasminogen
Tenecteplase thrombolysis	Tenecteplase thrombolysis	Xuanwu Hospital, Beijing	marketed	Fibrinolytic agent / Thrombolytic	Fibrin; Plasminogen
reteplase 10+10 U	reteplase 10+10 U	Sahlgrenska University Hospital	marketed	Fibrinolytic agent; tissue plasminogen activator (tPA) analog	Fibrin; plasminogen
Intra-Arterial TNK and Albumin	Intra-Arterial TNK and Albumin	Tianjin Huanhu Hospital	phase 3	Thrombolytic agent with albumin carrier	Fibrin; plasminogen
thrombolysis therapy	thrombolysis therapy	Leiden University Medical Center	phase 3	Thrombolytic agent	Fibrin; plasminogen/plasmin pathway

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Fibrinolytic agent; tissue plasminogen activator (tPA) class)

Cedars-Sinai Medical Center · 1 drug in this class
Hui-Sheng Chen · 1 drug in this class
The University of Texas Health Science Center, Houston · 1 drug in this class

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Cite this brief

Drug Landscape (2026). TNKase — Competitive Intelligence Brief. https://druglandscape.com/ci/tnkase. Accessed 2026-05-14.

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