Who are Aubagio's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Teriflunomide HMR1726, Leflunomide(LEF), Leflunomide 10 milligram (MG), FLUNIXIN, Leflunomide plus Methotrexate, IMU-838 tablets.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-14 · How we verify

Aubagio — Competitive Intelligence Brief

Aubagio (TERIFLUNOMIDE) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Pyrimidine Synthesis Inhibitor [EPC]. Area: Immunology.

marketed Pyrimidine Synthesis Inhibitor [EPC] dihydroorotate dehydrogenase Immunology Small molecule Live · refreshed every 30 min

Target snapshot

Aubagio (TERIFLUNOMIDE) — Sanofi. Teriflunomide inhibits dihydroorotate dehydrogenase, reducing activated lymphocytes in the CNS.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Aubagio TARGET	TERIFLUNOMIDE	Sanofi	marketed	Pyrimidine Synthesis Inhibitor [EPC]	dihydroorotate dehydrogenase	2012-01-01
Teriflunomide HMR1726	Teriflunomide HMR1726	Sanofi	marketed	Dihydroorotate dehydrogenase inhibitor; immunosuppressant	Dihydroorotate dehydrogenase (DHODH)
Leflunomide(LEF)	Leflunomide(LEF)	Nanjing Children's Hospital	marketed	Immunosuppressant; DHODH inhibitor	Dihydroorotate dehydrogenase (DHODH)
Leflunomide 10 milligram (MG)	Leflunomide 10 milligram (MG)	P. Verschueren	marketed	DHODH inhibitor; disease-modifying antirheumatic drug (DMARD)	Dihydroorotate dehydrogenase (DHODH)
FLUNIXIN	FLUNIXIN		marketed		Dihydroorotate dehydrogenase (quinone), mitochondrial
Leflunomide plus Methotrexate	Leflunomide plus Methotrexate	Bangladesh Medical University	marketed	Disease-modifying antirheumatic drug (DMARD) combination	Dihydroorotate dehydrogenase (leflunomide); Dihydrofolate reductase (methotrexate)
IMU-838 tablets	IMU-838 tablets	Immunic AG	phase 3	DHODH inhibitor	Dihydroorotate dehydrogenase (DHODH)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Pyrimidine Synthesis Inhibitor [EPC] class)

Sanofi · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Aubagio — Competitive Intelligence Brief. https://druglandscape.com/ci/teriflunomide. Accessed 2026-05-14.

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