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Tenofovir + lamivudine + raltegravir — Competitive Intelligence Brief
Target snapshot
Tenofovir + lamivudine + raltegravir (Tenofovir + lamivudine + raltegravir) — ANRS, Emerging Infectious Diseases. Tenofovir and lamivudine are nucleoside reverse transcriptase inhibitors (NRTIs) that block HIV replication by inhibiting viral DNA synthesis. Raltegravir is an integrase strand transfer inhibitor (INSTI) that blocks HIV replication by inhibiting viral integration into the host genome.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Tenofovir + lamivudine + raltegravir TARGET | Tenofovir + lamivudine + raltegravir | ANRS, Emerging Infectious Diseases | phase 3 | NRTI + INSTI | HIV integrase | |
| ELV/COBI/FTC/TAF | ELV/COBI/FTC/TAF | Fundacion SEIMC-GESIDA | marketed | Antiretroviral combination therapy (integrase inhibitor + NRTI + NtRTI + pharmacokinetic booster) | HIV integrase, HIV reverse transcriptase | |
| DTG/3TC/ABC + ELV/COBI/FTC/TAF | DTG/3TC/ABC + ELV/COBI/FTC/TAF | Fundacion SEIMC-GESIDA | marketed | Antiretroviral combination therapy (integrase inhibitor + nucleoside/nucleotide reverse transcriptase inhibitors) | HIV integrase, HIV reverse transcriptase | |
| Switch to DTG + 3TC | Switch to DTG + 3TC | Hospitales Universitarios Virgen del Rocío | marketed | Antiretroviral combination (INSTI + NRTI) | HIV integrase; HIV reverse transcriptase | |
| bictegravir/emtricitabine/tenofovir alafenamide | bictegravir/emtricitabine/tenofovir alafenamide | Midland Research Group, Inc. | marketed | Antiretroviral combination (integrase inhibitor + nucleoside reverse transcriptase inhibitors) | HIV integrase, HIV reverse transcriptase | |
| dolutegravir/abacavir/lamivudine | dolutegravir/abacavir/lamivudine | University College Dublin | marketed | Antiretroviral combination (INSTI + NRTIs) | HIV integrase, HIV reverse transcriptase | |
| Long-acting Cabotegravir injection | Long-acting Cabotegravir injection | MU-JHU CARE | marketed | Integrase strand transfer inhibitor (INSTI) | HIV integrase |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (NRTI + INSTI class)
- ANRS, Emerging Infectious Diseases · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Tenofovir + lamivudine + raltegravir — Competitive Intelligence Brief. https://druglandscape.com/ci/tenofovir-lamivudine-raltegravir. Accessed 2026-05-16.
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