Who are Tafenoquine prophylaxis's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Atovaquone Proguanil and Artesunate Pyronaridine, PQ unsupervised, PQ supervised, Supervised primaquine treatment, Unsupervised primaquine treatment, PQ (0.75).

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Last reviewed 2026-06-10 · How we verify

Tafenoquine prophylaxis — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Tafenoquine prophylaxis (Tafenoquine prophylaxis) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: 8-aminoquinoline antimalarial. Area: Infectious Disease.

marketed 8-aminoquinoline antimalarial Plasmodium mitochondrial electron transport chain Infectious Disease Small molecule Live · refreshed every 30 min

Target snapshot

Tafenoquine prophylaxis (Tafenoquine prophylaxis) — Naval Medical Research Center. Tafenoquine is an 8-aminoquinoline that kills malaria parasites by generating reactive oxygen species in the parasite mitochondria.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Tafenoquine prophylaxis TARGET	Tafenoquine prophylaxis	Naval Medical Research Center	marketed	8-aminoquinoline antimalarial	Plasmodium mitochondrial electron transport chain
Atovaquone Proguanil and Artesunate Pyronaridine	Atovaquone Proguanil and Artesunate Pyronaridine	Armed Forces Research Institute of Medical Sciences, Thailand	marketed	Antimalarial combination	Plasmodium mitochondrial electron transport chain, dihydrofolate reductase, heme polymerase
PQ unsupervised	PQ unsupervised	Menzies School of Health Research	marketed	8-aminoquinoline antimalarial	Plasmodium hypnozoite mitochondria
PQ supervised	PQ supervised	Menzies School of Health Research	marketed	8-aminoquinoline antimalarial	Plasmodium hypnozoites (mechanism not fully elucidated at molecular level)
Supervised primaquine treatment	Supervised primaquine treatment	Menzies School of Health Research	marketed	8-aminoquinoline antimalarial	Plasmodium parasite mitochondria and DNA
Unsupervised primaquine treatment	Unsupervised primaquine treatment	Menzies School of Health Research	marketed	8-aminoquinoline antimalarial	Malaria parasite mitochondria and DNA (indirect via oxidative stress)
PQ (0.75)	PQ (0.75)	London School of Hygiene and Tropical Medicine	phase 3	8-aminoquinoline antimalarial	Plasmodium hypnozoite (liver stage parasite)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (8-aminoquinoline antimalarial class)

Menzies School of Health Research · 5 drugs in this class
London School of Hygiene and Tropical Medicine · 2 drugs in this class
Naval Medical Research Center · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Tafenoquine prophylaxis — Competitive Intelligence Brief. https://druglandscape.com/ci/tafenoquine-prophylaxis. Accessed 2026-06-10.

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