Who are Tacrolimus and Sirolimus's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Tacrolimus and Everolimus, Tacrolimus/Sirolimus.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

Tacrolimus and Sirolimus — Competitive Intelligence Brief

Tacrolimus and Sirolimus (Tacrolimus and Sirolimus) competitive landscape: 2 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Calcineurin inhibitor and mTOR inhibitor combination. Area: Immunology / Transplantation.

marketed Calcineurin inhibitor and mTOR inhibitor combination Calcineurin (tacrolimus) and mTOR (sirolimus) Immunology / Transplantation Small molecule Live · refreshed every 30 min

Target snapshot

Tacrolimus and Sirolimus (Tacrolimus and Sirolimus) — Foundation for Liver Research. Tacrolimus and sirolimus are immunosuppressive agents that inhibit T-cell activation and proliferation through different pathways to prevent organ rejection.

Comparator set (2 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Tacrolimus and Sirolimus TARGET	Tacrolimus and Sirolimus	Foundation for Liver Research	marketed	Calcineurin inhibitor and mTOR inhibitor combination	Calcineurin (tacrolimus) and mTOR (sirolimus)
Tacrolimus and Everolimus	Tacrolimus and Everolimus	Chang Gung Memorial Hospital	marketed	Immunosuppressant (calcineurin inhibitor and mTOR inhibitor combination)	Calcineurin (tacrolimus) and mTOR (everolimus)
Tacrolimus/Sirolimus	Tacrolimus/Sirolimus	University of Miami	marketed	Calcineurin inhibitor and mTOR inhibitor combination	Calcineurin (tacrolimus) and mTOR (sirolimus)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Calcineurin inhibitor and mTOR inhibitor combination class)

Foundation for Liver Research · 1 drug in this class
University of Miami · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Tacrolimus and Sirolimus — Competitive Intelligence Brief. https://druglandscape.com/ci/tacrolimus-and-sirolimus. Accessed 2026-05-16.

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