Who are Systane Complete Preservative-Free's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): methylcellulose 0.5%, carboxymethylcellulose 0.5% +glycerin 0.9%, Optive®, Nature's Tears, Sodium Hyaluronate Ophthalmic 0.4%, Blink tears.

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Last reviewed 2026-05-17 · How we verify

Systane Complete Preservative-Free — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Systane Complete Preservative-Free (Systane Complete Preservative-Free) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Artificial tear / Ocular lubricant. Area: Ophthalmology.

marketed Artificial tear / Ocular lubricant Ophthalmology Small molecule Live · refreshed every 30 min

Target snapshot

Systane Complete Preservative-Free (Systane Complete Preservative-Free) — University of Waterloo. Systane Complete Preservative-Free is an artificial tear solution that lubricates and protects the ocular surface to relieve dry eye symptoms.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class
Systane Complete Preservative-Free TARGET	Systane Complete Preservative-Free	University of Waterloo	marketed	Artificial tear / Ocular lubricant
methylcellulose 0.5%	methylcellulose 0.5%	Clinica Oftamologica Zona Sul	marketed	Artificial tear / Ocular lubricant
carboxymethylcellulose 0.5% +glycerin 0.9%	carboxymethylcellulose 0.5% +glycerin 0.9%	Allergan	marketed	Artificial tear / ocular lubricant
Optive®	Optive®	Laboratorios Sophia S.A de C.V.	marketed	Artificial tear / Ocular lubricant
Nature's Tears	Nature's Tears	Aultman Health Foundation	marketed	Artificial tear / Ocular lubricant
Sodium Hyaluronate Ophthalmic 0.4%	Sodium Hyaluronate Ophthalmic 0.4%	Laboratorios Sophia S.A de C.V.	marketed	Artificial tear / Ocular lubricant
Blink tears	Blink tears	Medical University of South Carolina	marketed	Artificial tear / Ocular lubricant

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Artificial tear / Ocular lubricant class)

Laboratorios Sophia S.A de C.V. · 7 drugs in this class
Allergan · 3 drugs in this class
University of Waterloo · 2 drugs in this class
University of California, Berkeley · 2 drugs in this class
Bp Consulting, Inc · 1 drug in this class
Chong Kun Dang Pharmaceutical · 1 drug in this class
Clinica Oftamologica Zona Sul · 1 drug in this class
Fundação Altino Ventura · 1 drug in this class
Medical University of South Carolina · 1 drug in this class
Ocuwize LTD · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Systane Complete Preservative-Free — Competitive Intelligence Brief. https://druglandscape.com/ci/systane-complete-preservative-free. Accessed 2026-05-17.

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