Who are Sodium Oxybate (SMO)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Lioresal, placebo + oral baclofen, Low Sodium Oxybate, Xyrem, Baclofen ER, PXT3003 dose 1.

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Last reviewed 2026-05-17 · How we verify

Sodium Oxybate (SMO) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Sodium Oxybate (SMO) (Sodium Oxybate (SMO)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: GABA-B receptor agonist; CNS depressant. Area: Neurology.

marketed GABA-B receptor agonist; CNS depressant GABA-B receptor Neurology Small molecule Live · refreshed every 30 min

Target snapshot

Sodium Oxybate (SMO) (Sodium Oxybate (SMO)) — Catholic University of the Sacred Heart. Sodium oxybate is a central nervous system depressant that acts as a GABA-B receptor agonist and GHB (gamma-hydroxybutyrate) precursor to promote sleep and reduce excessive daytime sleepiness.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Sodium Oxybate (SMO) TARGET	Sodium Oxybate (SMO)	Catholic University of the Sacred Heart	marketed	GABA-B receptor agonist; CNS depressant	GABA-B receptor
Lioresal	BACLOFEN		marketed	gamma-Aminobutyric Acid-ergic Agonist [EPC]	GABA-B receptor	1977-01-01
placebo + oral baclofen	placebo + oral baclofen	Shaare Zedek Medical Center	marketed	GABA-B receptor agonist	GABA-B receptor
Low Sodium Oxybate	Low Sodium Oxybate	Leiden University Medical Center	marketed	GHB receptor agonist / GABA-B receptor agonist	GHB receptor, GABA-B receptor
Xyrem	Xyrem	Jazz Pharmaceuticals	marketed		Calcium/calmodulin-dependent protein kinase type II subunit alpha, GABA-B receptor, Gamma-hydroxybutyrate receptor
Baclofen ER	Baclofen ER	Alkermes, Inc.	marketed	GABA-B receptor agonist	GABA-B receptor
PXT3003 dose 1	PXT3003 dose 1	Pharnext S.C.A.	phase 3	Fixed-dose combination / Immunomodulator	Multiple targets (baclofen: GABA-B receptor; naltrexone: opioid receptors; sorbitol: osmotic agent)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2037-09-08 — Lioresal · 11446246 · Method of Use · US
2037-09-29 — Lioresal · 11324696 · Formulation · US
2039-07-29 — Lioresal · 11654124 · Formulation · US
2039-07-29 — Lioresal · 10792262 · Formulation · US
2039-07-29 — Lioresal · 11931328 · Formulation · US
2039-08-30 — Lioresal · 10610502 · Method of Use · US
2041-09-29 — Lioresal · 11850225 · Formulation · US
2041-09-29 — Lioresal · 11491125 · Formulation · US

Sponsor landscape (GABA-B receptor agonist; CNS depressant class)

Catholic University of the Sacred Heart · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Sodium Oxybate (SMO) — Competitive Intelligence Brief. https://druglandscape.com/ci/sodium-oxybate-smo. Accessed 2026-05-17.

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