Last reviewed · How we verify
SOC: Soluble guanylate cyclase stimulator — Competitive Intelligence Brief
phase 3
Soluble guanylate cyclase stimulator
Soluble guanylate cyclase (sGC)
Cardiovascular
Small molecule
Live · refreshed every 30 min
Target snapshot
SOC: Soluble guanylate cyclase stimulator (SOC: Soluble guanylate cyclase stimulator) — Actelion. Soluble guanylate cyclase stimulators directly activate the enzyme soluble guanylate cyclase to increase intracellular cyclic GMP levels, promoting vasodilation and reducing pulmonary vascular resistance.
Comparator set (5 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| SOC: Soluble guanylate cyclase stimulator TARGET | SOC: Soluble guanylate cyclase stimulator | Actelion | phase 3 | Soluble guanylate cyclase stimulator | Soluble guanylate cyclase (sGC) | |
| Verquvo | VERICIGUAT | Merck & Co. | marketed | Soluble Guanylate Cyclase Stimulator [EPC] | Guanylate cyclase soluble subunit beta-1 | 2021-01-01 |
| Adempas | RIOCIGUAT | Bayer | marketed | Soluble Guanylate Cyclase Stimulator [EPC] | Guanylate cyclase soluble subunit beta-1 | 2013-01-01 |
| Riociguat Oral Product | Riociguat Oral Product | University of Calgary | marketed | Soluble guanylate cyclase stimulator | Soluble guanylate cyclase (sGC) | |
| Riociguat (Adempas) | Riociguat (Adempas) | Chinese University of Hong Kong | marketed | Soluble guanylate cyclase stimulator | Soluble guanylate cyclase (sGC) | |
| Riociguat Pill | Riociguat Pill | University of Arizona | phase 3 | Soluble guanylate cyclase stimulator | Soluble guanylate cyclase (sGC) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Soluble guanylate cyclase stimulator class)
- Actelion · 1 drug in this class
- Chinese University of Hong Kong · 1 drug in this class
- University of Arizona · 1 drug in this class
- University of Calgary · 1 drug in this class
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Cite this brief
Drug Landscape (2026). SOC: Soluble guanylate cyclase stimulator — Competitive Intelligence Brief. https://druglandscape.com/ci/soc-soluble-guanylate-cyclase-stimulator. Accessed 2026-05-16.
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