Who are Sertraline HCl's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Lexapro, Prozac, Lexapro (escitalopram), Escitalopram (Lexapro), Placebo & Citalopram, Low severity group: Escitalopram.

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Last reviewed 2026-06-10 · How we verify

Sertraline HCl — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Sertraline HCl (Sertraline HCl) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Selective serotonin reuptake inhibitor (SSRI). Area: Psychiatry / Neurology.

marketed Selective serotonin reuptake inhibitor (SSRI) Serotonin transporter (SERT) Psychiatry / Neurology Small molecule Live · refreshed every 30 min

Target snapshot

Sertraline HCl (Sertraline HCl) — Tri-Service General Hospital. Sertraline selectively inhibits the reuptake of serotonin at the neuronal synapse, increasing serotonin availability in the brain.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Sertraline HCl TARGET	Sertraline HCl	Tri-Service General Hospital	marketed	Selective serotonin reuptake inhibitor (SSRI)	Serotonin transporter (SERT)
Lexapro	escitalopram	Generic (originally Lundbeck/Forest)	marketed	Selective Serotonin Reuptake Inhibitor (SSRI)	Serotonin (5-HT) reuptake transporter	2002-08-14
Prozac	fluoxetine	Eli Lilly and Company	marketed	Selective Serotonin Reuptake Inhibitor (SSRI)	Serotonin reuptake transporter	1987-12-29
Lexapro (escitalopram)	Lexapro (escitalopram)	St. Luke's-Roosevelt Hospital Center	marketed	Selective serotonin reuptake inhibitor (SSRI)	Serotonin transporter (SERT)
Escitalopram (Lexapro)	Escitalopram (Lexapro)	University of Rochester	marketed	Selective serotonin reuptake inhibitor (SSRI)	Serotonin transporter (SERT)
Placebo & Citalopram	Placebo & Citalopram	University of Colorado, Denver	marketed	Selective serotonin reuptake inhibitor (SSRI)	Serotonin transporter (SERT)
Low severity group: Escitalopram	Low severity group: Escitalopram	University of Texas Southwestern Medical Center	marketed	Selective serotonin reuptake inhibitor (SSRI)	Serotonin transporter (SERT)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Selective serotonin reuptake inhibitor (SSRI) class)

University of Texas Southwestern Medical Center · 3 drugs in this class
Johns Hopkins University · 2 drugs in this class
GlaxoSmithKline · 2 drugs in this class
Daiichi Sankyo Co., Ltd. · 1 drug in this class
Guangdong Provincial People's Hospital · 1 drug in this class
Janssen Research & Development, LLC · 1 drug in this class
Medical University of Vienna · 1 drug in this class
Massachusetts General Hospital · 1 drug in this class
Fundació Sant Joan de Déu · 1 drug in this class
Centre Hospitalier Universitaire Dijon · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Sertraline HCl — Competitive Intelligence Brief. https://druglandscape.com/ci/sertraline-hcl. Accessed 2026-06-10.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing