Who are Zoloft's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Sertralin, Placebo and SSRI, Paroxetine + relaxation.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-13 · How we verify

Zoloft — Competitive Intelligence Brief

Zoloft (sertraline) competitive landscape: 3 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: SSRI (Selective serotonin reuptake inhibitor). Area: Neuroscience.

marketed SSRI (Selective serotonin reuptake inhibitor) Cytochrome P450 2C19, Melanocortin receptor 5, 5-hydroxytryptamine receptor 2A Neuroscience Small molecule Live · refreshed every 30 min

Target snapshot

Zoloft (sertraline) — Pfizer Inc.. Selective serotonin reuptake inhibitor (SSRI) that blocks the serotonin transporter, increasing synaptic serotonin to improve mood and reduce anxiety.

Comparator set (3 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Zoloft TARGET	sertraline	Pfizer Inc.	marketed	SSRI (Selective serotonin reuptake inhibitor)	Cytochrome P450 2C19, Melanocortin receptor 5, 5-hydroxytryptamine receptor 2A	1991-12-30
Sertralin	Sertralin	Poznan University of Medical Sciences	marketed		Cytochrome P450 2C19, Melanocortin receptor 5, 5-hydroxytryptamine receptor 2A
Placebo and SSRI	Placebo and SSRI	All India Institute of Medical Sciences, Bhubaneswar	marketed	SSRI (Selective Serotonin Reuptake Inhibitor)	Serotonin transporter (SERT)
Paroxetine + relaxation	Paroxetine + relaxation	University of Göttingen	marketed	SSRI (Selective Serotonin Reuptake Inhibitor)	Serotonin transporter (SERT)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (SSRI (Selective serotonin reuptake inhibitor) class)

Pfizer Inc. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Zoloft — Competitive Intelligence Brief. https://druglandscape.com/ci/sertraline. Accessed 2026-05-13.

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