Who are Ekterly's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Orladeyo, Takhzyro, Kalbitor, TAKHZYRO, BCX7353 capsules.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-14 · How we verify

Ekterly — Competitive Intelligence Brief

Ekterly (SEBETRALSTAT) competitive landscape: 5 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Plasma Kallikrein Inhibitor [EPC]. Area: Other.

marketed Plasma Kallikrein Inhibitor [EPC] Other Small molecule Live · refreshed every 30 min

Target snapshot

Ekterly (SEBETRALSTAT) — Kalvista. Ekterly works by blocking the plasma kallikrein enzyme, which is involved in the production of bradykinin, a key mediator of HAE symptoms.

Comparator set (5 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Ekterly TARGET	SEBETRALSTAT	Kalvista	marketed	Plasma Kallikrein Inhibitor [EPC]		2025-01-01
Orladeyo	BEROTRALSTAT	Biocryst	marketed	Plasma Kallikrein Inhibitor	Plasma kallikrein	2020-01-01
Takhzyro	LANADELUMAB	Dyax Corp	marketed	Plasma Kallikrein Inhibitor [EPC]	plasma kallikrein	2018-01-01
Kalbitor	ECALLANTIDE	Dyax Corp.	marketed	Plasma Kallikrein Inhibitor [EPC]	Plasma kallikrein	2009-01-01
TAKHZYRO	LANADELUMAB-FLYO	DYAX CORP.	marketed	Plasma Kallikrein Inhibitor [EPC]	Plasma kallikrein
BCX7353 capsules	BCX7353 capsules	BioCryst Pharmaceuticals	phase 3	Plasma kallikrein inhibitor	Plasma kallikrein (Factor XIa)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Plasma Kallikrein Inhibitor [EPC] class)

DYAX CORP. · 1 drug in this class
Dyax Corp · 1 drug in this class
Dyax Corp. · 1 drug in this class
Kalvista · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Ekterly — Competitive Intelligence Brief. https://druglandscape.com/ci/sebetralstat. Accessed 2026-05-14.

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