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S-1 plus Cisplatin — Competitive Intelligence Brief
phase 3
Antineoplastic agents
Thymidylate synthase, DNA
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
S-1 plus Cisplatin (S-1 plus Cisplatin) — Taiho Pharmaceutical Co., Ltd.. S-1 is a fluoropyrimidine derivative that inhibits thymidylate synthase, while cisplatin is a platinum-based alkylating agent that cross-links DNA, thereby inhibiting DNA replication and transcription.
Comparator set (4 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| S-1 plus Cisplatin TARGET | S-1 plus Cisplatin | Taiho Pharmaceutical Co., Ltd. | phase 3 | Antineoplastic agents | Thymidylate synthase, DNA | |
| Placebo、CAPOX | Placebo、CAPOX | Suzhou Suncadia Biopharmaceuticals Co., Ltd. | phase 3 | chemotherapy regimen | thymidylate synthase, DNA repair enzymes | |
| FOLFOXIRI with bevacizumab | FOLFOXIRI with bevacizumab | Dutch Colorectal Cancer Group | phase 3 | Chemotherapy combination with anti-angiogenic monoclonal antibody | VEGF (bevacizumab component); topoisomerase I, thymidylate synthase, DNA (FOLFOXIRI components) | |
| cetuximab + cisplatin + vinorelbine | cetuximab + cisplatin + vinorelbine | Merck KGaA, Darmstadt, Germany | phase 3 | Antineoplastic agents | EGFR | |
| cytarabine and mitoxantrone | cytarabine and mitoxantrone | Pfizer | phase 3 | Antineoplastic agents |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Antineoplastic agents class)
- Asan Medical Center · 1 drug in this class
- Central European Cooperative Oncology Group · 1 drug in this class
- Croatian Cooperative Group for Clinical Research in Oncology · 1 drug in this class
- Eli Lilly and Company · 1 drug in this class
- Groupe Oncologie Radiotherapie Tete et Cou · 1 drug in this class
- Merck KGaA, Darmstadt, Germany · 1 drug in this class
- Pfizer · 1 drug in this class
- Taiho Pharmaceutical Co., Ltd. · 1 drug in this class
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Cite this brief
Drug Landscape (2026). S-1 plus Cisplatin — Competitive Intelligence Brief. https://druglandscape.com/ci/s-1-plus-cisplatin. Accessed 2026-06-10.
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