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S-1 + Cisplatin (arm A) — Competitive Intelligence Brief
phase 3
Fluoropyrimidine + platinum-based chemotherapy combination
Thymidylate synthase (S-1); DNA (cisplatin)
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
S-1 + Cisplatin (arm A) (S-1 + Cisplatin (arm A)) — Taiho Pharmaceutical Co., Ltd.. S-1 is an oral fluoropyrimidine prodrug that inhibits thymidylate synthase and other enzymes in nucleotide synthesis, while cisplatin is a platinum-based alkylating agent that cross-links DNA, together producing synergistic cytotoxic effects against cancer cells.
Comparator set (2 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| S-1 + Cisplatin (arm A) TARGET | S-1 + Cisplatin (arm A) | Taiho Pharmaceutical Co., Ltd. | phase 3 | Fluoropyrimidine + platinum-based chemotherapy combination | Thymidylate synthase (S-1); DNA (cisplatin) | |
| S-1 & Oxaliplatin | S-1 & Oxaliplatin | The First Affiliated Hospital with Nanjing Medical University | phase 3 | Fluoropyrimidine + platinum-based chemotherapy combination | Thymidylate synthase (S-1); DNA (oxaliplatin) | |
| TS-1, oxaliplatin | TS-1, oxaliplatin | Samsung Medical Center | phase 3 | Fluoropyrimidine + platinum-based chemotherapy combination | Thymidylate synthase; DNA (platinum crosslinking) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Fluoropyrimidine + platinum-based chemotherapy combination class)
- Samsung Medical Center · 1 drug in this class
- Taiho Pharmaceutical Co., Ltd. · 1 drug in this class
- The First Affiliated Hospital with Nanjing Medical University · 1 drug in this class
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Cite this brief
Drug Landscape (2026). S-1 + Cisplatin (arm A) — Competitive Intelligence Brief. https://druglandscape.com/ci/s-1-cisplatin-arm-a. Accessed 2026-05-16.
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