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quetiapine fumarate vs risperidone — Competitive Intelligence Brief
marketed
Atypical antipsychotic
Dopamine D2 receptor, serotonin 5-HT2A receptor
Psychiatry/Neurology
Small molecule
Live · refreshed every 30 min
Target snapshot
quetiapine fumarate vs risperidone (quetiapine fumarate vs risperidone) — AstraZeneca. Quetiapine fumarate is an atypical antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors in the brain, while risperidone is a similar atypical antipsychotic with higher D2 receptor affinity and additional alpha-adrenergic blocking activity.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| quetiapine fumarate vs risperidone TARGET | quetiapine fumarate vs risperidone | AstraZeneca | marketed | Atypical antipsychotic | Dopamine D2 receptor, serotonin 5-HT2A receptor | |
| full-dose olanzapine | full-dose olanzapine | Kaohsiung Kai-Suan Psychiatric Hospital | marketed | Atypical antipsychotic | Dopamine D2 receptor, Serotonin 5-HT2A receptor | |
| Risperidone, Haloperidol | Risperidone, Haloperidol | Ludwig-Maximilians - University of Munich | marketed | Antipsychotic | Dopamine D2 receptor, Serotonin 5-HT2A receptor | |
| Lithium carbonate + perospirone hydrochloride | Lithium carbonate + perospirone hydrochloride | Shanghai Mental Health Center | marketed | Mood stabilizer + atypical antipsychotic combination | Inositol monophosphatase, GSK-3 (lithium); dopamine D2 receptor, serotonin 5-HT2A receptor (perospirone) | |
| Risperidone and Ramelteon | Risperidone and Ramelteon | All India Institute of Medical Sciences, Bhubaneswar | marketed | Atypical antipsychotic + melatonin receptor agonist combination | Dopamine D2 receptor, serotonin 5-HT2A receptor, melatonin MT1/MT2 receptors | |
| Quetiapine (drug) | Quetiapine (drug) | Medical University of Vienna | marketed | Atypical antipsychotic | Dopamine D2 receptor, Serotonin 5-HT2A receptor | |
| Risperdal Consta | Risperdal Consta | Zogenix, Inc. | marketed | Atypical antipsychotic | Dopamine D2 receptor, Serotonin 5-HT2A receptor |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Atypical antipsychotic class)
- Shanghai Mental Health Center · 10 drugs in this class
- AstraZeneca · 6 drugs in this class
- Otsuka Pharmaceutical Development & Commercialization, Inc. · 5 drugs in this class
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C. · 4 drugs in this class
- Eli Lilly and Company · 4 drugs in this class
- Otsuka Pharmaceutical Co., Ltd. · 3 drugs in this class
- Medical University of Vienna · 2 drugs in this class
- Organon and Co · 2 drugs in this class
- Chengdu Kanghong Pharmaceutical Group Co., Ltd. · 2 drugs in this class
- H. Lundbeck A/S · 2 drugs in this class
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Cite this brief
Drug Landscape (2026). quetiapine fumarate vs risperidone — Competitive Intelligence Brief. https://druglandscape.com/ci/quetiapine-fumarate-vs-risperidone. Accessed 2026-05-17.
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