Who are Protopic (R)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Elidel, Prograf, Sandimmune, CYCLOSPORINE, Sandimmune, Ciclosporin A (CsA).

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-13 · How we verify

Protopic (R) — Competitive Intelligence Brief

Protopic (R) (Protopic (R)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Calcineurin inhibitor. Area: Dermatology/Immunology.

phase 3 Calcineurin inhibitor Calcineurin (protein phosphatase 2B) Dermatology/Immunology Small molecule Live · refreshed every 30 min

Target snapshot

Protopic (R) (Protopic (R)) — University Hospital, Rouen. Protopic (tacrolimus) is a calcineurin inhibitor that suppresses T-cell activation and cytokine production to reduce inflammatory skin responses.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Protopic (R) TARGET	Protopic (R)	University Hospital, Rouen	phase 3	Calcineurin inhibitor	Calcineurin (protein phosphatase 2B)
Elidel	PIMECROLIMUS	Bausch Health	marketed	Calcineurin Inhibitor Immunosuppressant [EPC]	Peptidyl-prolyl cis-trans isomerase FKBP1A	2001-01-01
Prograf	TACROLIMUS	Astellas Pharma	marketed	Calcineurin Inhibitor Immunosuppressant	Interferon gamma	1994-01-01
Sandimmune	cyclosporine	Novartis AG (originally Sandoz)	marketed	Calcineurin inhibitor (immunosuppressant)	Calcineurin subunit B type 1, Canalicular multispecific organic anion transporter 1, Canalicular multispecific organic anion transporter 2	1983-11-14
CYCLOSPORINE	CYCLOSPORINE		marketed	Calcineurin Inhibitor Immunosuppressant [EPC]	calcineurin	1983-01-01
Sandimmune	Ciclosporin	Novartis	marketed	Calcineurin Inhibitor Immunosuppressant [EPC]	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	1983-01-01
Ciclosporin A (CsA)	Ciclosporin A (CsA)	Nanfang Hospital, Southern Medical University	marketed	Calcineurin inhibitor	Calcineurin (protein phosphatase 2B)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2027-11-03 — Sandimmune · 8298568 · Formulation · US
2027-11-03 — Sandimmune · 8298568 · US
2028-05-30 — Prograf · 9549918 · Formulation · US
2028-05-30 — Prograf · 10166190 · Formulation · US
2028-05-30 — Prograf · 11419823 · Formulation · US
2028-05-30 — Prograf · 12403095 · Formulation · US
2028-05-30 — Prograf · 11123331 · Method of Use · US
2028-05-30 — Prograf · 11110081 · Method of Use · US
2028-05-30 — Prograf · 12083103 · Method of Use · US
2028-05-30 — Prograf · 10864199 · Method of Use · US
2028-08-30 — Prograf · 8664239 · Method of Use · US
2028-08-30 — Prograf · 8685998 · Formulation · US
2029-06-02 — Sandimmune · 9132071 · US
2029-06-02 — Sandimmune · 9132071 · Formulation · US
2030-12-13 — Sandimmune · 8614178 · US
2030-12-13 — Sandimmune · 8614178 · Formulation · US
2031-02-25 — Sandimmune · 8292129 · Formulation · US
2031-02-25 — Sandimmune · 8292129 · US
2032-04-16 — Sandimmune · 8561859 · US
2032-04-16 — Sandimmune · 8561859 · Formulation · US
2033-08-23 — Sandimmune · 9937225 · US
2033-08-23 — Sandimmune · 8980839 · US
2033-08-23 — Sandimmune · 10441630 · US
2033-08-23 — Sandimmune · 8980839 · Formulation · US
2033-08-23 — Sandimmune · 9937225 · Formulation · US
2033-08-23 — Sandimmune · 10441630 · Formulation · US
2034-02-07 — Sandimmune · 9676525 · US
2034-02-07 — Sandimmune · 9676525 · Formulation · US
2034-05-11 — Sandimmune · 9669974 · Formulation · US
2034-05-11 — Sandimmune · 9669974 · US

Sponsor landscape (Calcineurin inhibitor class)

Novartis · 4 drugs in this class
Astellas Pharma Inc · 4 drugs in this class
Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. · 4 drugs in this class
University of Cincinnati · 3 drugs in this class
Allergan · 3 drugs in this class
Astellas Pharma China, Inc. · 3 drugs in this class
Novaliq GmbH · 3 drugs in this class
Hoffmann-La Roche · 3 drugs in this class
LEO Pharma · 3 drugs in this class
Santen SAS · 3 drugs in this class

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Cite this brief

Drug Landscape (2026). Protopic (R) — Competitive Intelligence Brief. https://druglandscape.com/ci/protopic-r. Accessed 2026-05-13.

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