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PQ (0.75) — Competitive Intelligence Brief
phase 3
8-aminoquinoline antimalarial
Plasmodium hypnozoite (liver stage parasite)
Infectious Disease / Parasitology
Small molecule
Live · refreshed every 30 min
Target snapshot
PQ (0.75) (PQ (0.75)) — London School of Hygiene and Tropical Medicine. PQ is a primaquine analog that acts as an 8-aminoquinoline antimalarial targeting the hypnozoite stage of Plasmodium parasites in the liver.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| PQ (0.75) TARGET | PQ (0.75) | London School of Hygiene and Tropical Medicine | phase 3 | 8-aminoquinoline antimalarial | Plasmodium hypnozoite (liver stage parasite) | |
| PQ supervised | PQ supervised | Menzies School of Health Research | marketed | 8-aminoquinoline antimalarial | Plasmodium hypnozoites (mechanism not fully elucidated at molecular level) | |
| PQ unsupervised | PQ unsupervised | Menzies School of Health Research | marketed | 8-aminoquinoline antimalarial | Plasmodium hypnozoite mitochondria | |
| Tafenoquine prophylaxis | Tafenoquine prophylaxis | Naval Medical Research Center | marketed | 8-aminoquinoline antimalarial | Plasmodium mitochondrial electron transport chain | |
| Supervised primaquine treatment | Supervised primaquine treatment | Menzies School of Health Research | marketed | 8-aminoquinoline antimalarial | Plasmodium parasite mitochondria and DNA | |
| Unsupervised primaquine treatment | Unsupervised primaquine treatment | Menzies School of Health Research | marketed | 8-aminoquinoline antimalarial | Malaria parasite mitochondria and DNA (indirect via oxidative stress) | |
| High dose ultra short Primaquine | High dose ultra short Primaquine | Menzies School of Health Research | phase 3 | 8-aminoquinoline antimalarial | Malaria parasite (Plasmodium spp.) — mechanism involves oxidative stress generation |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (8-aminoquinoline antimalarial class)
- Menzies School of Health Research · 5 drugs in this class
- London School of Hygiene and Tropical Medicine · 2 drugs in this class
- Naval Medical Research Center · 1 drug in this class
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Cite this brief
Drug Landscape (2026). PQ (0.75) — Competitive Intelligence Brief. https://druglandscape.com/ci/pq-0-75. Accessed 2026-05-15.
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