Who are PPI (proton pump inhibitor)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Dexilant, Nexium, Protonix, Protonix, Pantoprazole Sodium, Aciphex.

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Last reviewed 2026-05-14 · How we verify

PPI (proton pump inhibitor) — Competitive Intelligence Brief

PPI (proton pump inhibitor) (PPI (proton pump inhibitor)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Proton pump inhibitor. Area: Gastroenterology.

marketed Proton pump inhibitor H+/K+-ATPase (proton pump) Gastroenterology Small molecule Live · refreshed every 30 min

Target snapshot

PPI (proton pump inhibitor) (PPI (proton pump inhibitor)) — University of Bologna. Proton pump inhibitors block the hydrogen/potassium ATPase enzyme in gastric parietal cells, reducing gastric acid secretion.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
PPI (proton pump inhibitor) TARGET	PPI (proton pump inhibitor)	University of Bologna	marketed	Proton pump inhibitor	H+/K+-ATPase (proton pump)
Dexilant	DEXLANSOPRAZOLE	Takeda	marketed	Proton Pump Inhibitor [EPC]	(H+, K+)-ATPase	2009-01-01
Nexium	esomeprazole	AstraZeneca	marketed	Proton pump inhibitor (PPI)	Potassium-transporting ATPase	2001-02-20
Protonix	pantoprazole	Generic (originally Byk Gulden/Altana/Nycomed)	marketed	Proton pump inhibitor (PPI)	ATP-binding cassette sub-family G member 2, Fatty acid synthase, Multidrug and toxin extrusion protein 1	2000-02-02
Protonix	Pantoprazole Sodium	Baxter	marketed	Proton pump inhibitor (PPI)	(H+, K+)-ATPase enzyme system	2000-01-01
Pantoprazole Sodium	Pantoprazole Sodium	Pfizer	marketed	Proton pump inhibitor (PPI)	(H+, K+)-ATPase enzyme	2000-01-01
Aciphex	rabeprazole	Waylis	marketed	Proton Pump Inhibitor	Potassium-transporting ATPase	1999-01-01

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2026-06-07 — Pantoprazole Sodium · 7544370 · US
2026-12-07 — Pantoprazole Sodium · 7544370*PED · US

Sponsor landscape (Proton pump inhibitor class)

Samsung Medical Center · 2 drugs in this class
Bayer · 1 drug in this class
GBG Forschungs GmbH · 1 drug in this class
HK inno.N Corporation · 1 drug in this class
IBSA Institut Biochimique SA · 1 drug in this class
Jason Lang, M.D., M.P.H. · 1 drug in this class
Jun-Won Chung · 1 drug in this class
Merck Sharp & Dohme LLC · 1 drug in this class
Shandong New Time Pharmaceutical Co., LTD · 1 drug in this class
AVM Biotechnology Inc · 1 drug in this class

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Cite this brief

Drug Landscape (2026). PPI (proton pump inhibitor) — Competitive Intelligence Brief. https://druglandscape.com/ci/ppi-proton-pump-inhibitor. Accessed 2026-05-14.

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