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Placebo to omarigliptin — Competitive Intelligence Brief
phase 3
DPP-4 inhibitor
DPP-4 (dipeptidyl peptidase-4)
Diabetes
Small molecule
Live · refreshed every 30 min
Target snapshot
Placebo to omarigliptin (Placebo to omarigliptin) — Merck Sharp & Dohme LLC. Omarigliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases incretin hormone levels to stimulate insulin secretion and reduce glucagon in response to elevated blood glucose.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Placebo to omarigliptin TARGET | Placebo to omarigliptin | Merck Sharp & Dohme LLC | phase 3 | DPP-4 inhibitor | DPP-4 (dipeptidyl peptidase-4) | |
| Sitagliptin combined with metformin | Sitagliptin combined with metformin | Sun Yat-sen University | marketed | DPP-4 inhibitor combined with biguanide | DPP-4 enzyme; metformin acts on multiple targets including mitochondrial complex I | |
| sitagliptin and acarbose | sitagliptin and acarbose | Nanjing First Hospital, Nanjing Medical University | marketed | DPP-4 inhibitor + alpha-glucosidase inhibitor combination | DPP-4 enzyme; alpha-glucosidase enzymes | |
| Metformin and Saxagliptin | Metformin and Saxagliptin | ikfe-CRO GmbH | marketed | Biguanide + DPP-4 inhibitor combination | Metformin: mitochondrial glycerophosphate dehydrogenase; Saxagliptin: DPP-4 (dipeptidyl peptidase-4) | |
| DPP-4 inhibitor + metformin group | DPP-4 inhibitor + metformin group | Beni-Suef University | marketed | DPP-4 inhibitor + biguanide combination | DPP-4 enzyme; metformin acts on multiple targets including mitochondrial glycerophosphate dehydrogenase | |
| exenatide and sitagliptin | exenatide and sitagliptin | AstraZeneca | marketed | GLP-1 receptor agonist and DPP-4 inhibitor combination | GLP-1 receptor (exenatide); DPP-4 (sitagliptin) | |
| Sitagliptin (Januvia) | Sitagliptin (Januvia) | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | marketed | DPP-4 inhibitor | DPP-4 (dipeptidyl peptidase-4) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (DPP-4 inhibitor class)
- Merck Sharp & Dohme LLC · 5 drugs in this class
- Daewoong Pharmaceutical Co. LTD. · 4 drugs in this class
- AstraZeneca · 4 drugs in this class
- LG Life Sciences · 2 drugs in this class
- Tanabe Pharma Corporation · 2 drugs in this class
- Ain Shams University · 2 drugs in this class
- Ono Pharmaceutical Co. Ltd · 2 drugs in this class
- Cinnagen · 1 drug in this class
- GRADE Study Group · 1 drug in this class
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd. · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Placebo to omarigliptin — Competitive Intelligence Brief. https://druglandscape.com/ci/placebo-to-omarigliptin. Accessed 2026-05-17.
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