Who are Pioglitazone and Metformin's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Pioglitazone + Metformin, rosiglitazone-metformin, rosiglitazone and metformin combination tablet.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

Pioglitazone and Metformin — Competitive Intelligence Brief

Pioglitazone and Metformin (Pioglitazone and Metformin) competitive landscape: 3 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Thiazolidinedione + Biguanide combination. Area: Diabetes.

marketed Thiazolidinedione + Biguanide combination PPAR-γ (pioglitazone); Complex I of mitochondrial respiratory chain (metformin) Diabetes Small molecule Live · refreshed every 30 min

Target snapshot

Pioglitazone and Metformin (Pioglitazone and Metformin) — Takeda. Pioglitazone improves insulin sensitivity by activating PPAR-γ, while metformin reduces hepatic glucose production and improves peripheral insulin sensitivity, together lowering blood glucose in type 2 diabetes.

Comparator set (3 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Pioglitazone and Metformin TARGET	Pioglitazone and Metformin	Takeda	marketed	Thiazolidinedione + Biguanide combination	PPAR-γ (pioglitazone); Complex I of mitochondrial respiratory chain (metformin)
Pioglitazone + Metformin	Pioglitazone + Metformin	Sun Yat-sen University	marketed	Thiazolidinedione + Biguanide combination	PPAR-γ (pioglitazone); AMPK/mitochondrial complex I (metformin)
rosiglitazone-metformin	rosiglitazone-metformin	GlaxoSmithKline	marketed	Thiazolidinedione + Biguanide combination	PPAR-γ (rosiglitazone component); Complex mitochondrial mechanism (metformin component)
rosiglitazone and metformin combination tablet	rosiglitazone and metformin combination tablet	Novo Nordisk A/S	phase 3	Thiazolidinedione + Biguanide combination	PPAR-γ (rosiglitazone); Complex I of mitochondrial respiratory chain (metformin)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Thiazolidinedione + Biguanide combination class)

GlaxoSmithKline · 1 drug in this class
Novo Nordisk A/S · 1 drug in this class
Sun Yat-sen University · 1 drug in this class
Takeda · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Pioglitazone and Metformin — Competitive Intelligence Brief. https://druglandscape.com/ci/pioglitazone-and-metformin. Accessed 2026-05-16.

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