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Perioperative Pregabalin — Competitive Intelligence Brief
phase 3
Gabapentinoid; anticonvulsant; anxiolytic analgesic
Alpha-2-delta-1 subunit of voltage-gated calcium channels
Pain Management; Perioperative Medicine
Small molecule
Live · refreshed every 30 min
Target snapshot
Perioperative Pregabalin (Perioperative Pregabalin) — McMaster University. Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters and thereby decreasing neuropathic pain and anxiety.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Perioperative Pregabalin TARGET | Perioperative Pregabalin | McMaster University | phase 3 | Gabapentinoid; anticonvulsant; anxiolytic analgesic | Alpha-2-delta-1 subunit of voltage-gated calcium channels | |
| pregabalin capsules | pregabalin capsules | AstraZeneca | marketed | Gabapentinoid; anticonvulsant; anxiolytic | Alpha-2-delta-1 subunit of voltage-gated calcium channels | |
| Gabapentin Capsules | Gabapentin Capsules | EpiCept Corporation | marketed | Anticonvulsant; Gabapentinoid | Alpha-2-delta-1 subunit of voltage-gated calcium channels | |
| Standard dose gabapentin | Standard dose gabapentin | Mario Negri Institute for Pharmacological Research | marketed | Anticonvulsant; gabapentinoid | Alpha-2-delta-1 subunit of voltage-gated calcium channels | |
| Pregabalin add-on therapy | Pregabalin add-on therapy | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | phase 3 | Gabapentinoid | Alpha-2-delta-1 subunit of voltage-gated calcium channels | |
| Placebo matched with pregabalin | Placebo matched with pregabalin | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | phase 3 | Gabapentinoid | Alpha-2-delta-1 subunit of voltage-gated calcium channels | |
| Neurontin | gabapentin | Generic (originally Parke-Davis/Pfizer) | marketed | Gabapentinoid (anticonvulsant/neuropathic pain agent) | Large neutral amino acids transporter small subunit 1, Adenosine receptor A1, Alpha-2A adrenergic receptor | 1993-12-30 |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Gabapentinoid; anticonvulsant; anxiolytic analgesic class)
- McMaster University · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Perioperative Pregabalin — Competitive Intelligence Brief. https://druglandscape.com/ci/perioperative-pregabalin. Accessed 2026-06-10.
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