Who are Pemetrexed + oral folinic acid rescue's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Intrathecal injection of pemetrexed, nedaplatin+pemetrexed, Bevacizumab and Pemetrexed/platinum, Pemetrexed+carboplatin/Cisplatin, Pemetrexed+Cisplatin or Carboplatin, Pemetrexed plus Pembrolizumab.

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Last reviewed 2026-05-17 · How we verify

Pemetrexed + oral folinic acid rescue — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Pemetrexed + oral folinic acid rescue (Pemetrexed + oral folinic acid rescue) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Antifolate antimetabolite. Area: Oncology.

marketed Antifolate antimetabolite Thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formyltransferase Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Pemetrexed + oral folinic acid rescue (Pemetrexed + oral folinic acid rescue) — Radboud University Medical Center. Pemetrexed inhibits multiple folate-dependent enzymes involved in nucleotide synthesis, and oral folinic acid rescue protects normal cells from toxicity while allowing cancer cell death.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Pemetrexed + oral folinic acid rescue TARGET	Pemetrexed + oral folinic acid rescue	Radboud University Medical Center	marketed	Antifolate antimetabolite	Thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formyltransferase
Intrathecal injection of pemetrexed	Intrathecal injection of pemetrexed	Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	marketed	Antifolate antimetabolite	Thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formyltransferase
nedaplatin+pemetrexed	nedaplatin+pemetrexed	Sun Yat-sen University	phase 3	Platinum-based chemotherapy, Antifolate	DNA, Thymidylate synthase, Dihydrofolate reductase, Glycinamide ribonucleotide formyltransferase
Bevacizumab and Pemetrexed/platinum	Bevacizumab and Pemetrexed/platinum	Sun Yat-sen University	phase 3	Combination therapy: monoclonal antibody (anti-VEGF) + antifolate + platinum chemotherapy	VEGF (bevacizumab); thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formyltransferase (pemetrexed); DNA (platinum)
Pemetrexed+carboplatin/Cisplatin	Pemetrexed+carboplatin/Cisplatin	Suzhou Puhe Pharmaceutical Technology Co., LTD	phase 3	Antifolate antimetabolite + platinum-based chemotherapy combination	Thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formyltransferase; DNA (platinum agents)
Pemetrexed+Cisplatin or Carboplatin	Pemetrexed+Cisplatin or Carboplatin	Sichuan Baili Pharmaceutical Co., Ltd.	phase 3	Antifolate antimetabolite + platinum-based chemotherapy combination	Thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formyltransferase; DNA (platinum agents)
Pemetrexed plus Pembrolizumab	Pemetrexed plus Pembrolizumab	Hunan Province Tumor Hospital	phase 3	Antifolate antimetabolite + PD-1 inhibitor combination	Thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formyltransferase (pemetrexed); PD-1 (pembrolizumab)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Antifolate antimetabolite class)

Allist Pharmaceuticals, Inc. · 1 drug in this class
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · 1 drug in this class
Mundipharma K.K. · 1 drug in this class
Radboud University Medical Center · 1 drug in this class
Shanghai Miracogen Inc. · 1 drug in this class
The First Affiliated Hospital with Nanjing Medical University · 1 drug in this class
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Pemetrexed + oral folinic acid rescue — Competitive Intelligence Brief. https://druglandscape.com/ci/pemetrexed-oral-folinic-acid-rescue. Accessed 2026-05-17.

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