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Pemetrexed + cisplatin — Competitive Intelligence Brief
phase 3
Antifolate antimetabolite + platinum-based alkylating agent
Thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formyltransferase (pemetrexed); DNA (cisplatin)
Oncology
Small molecule
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Target snapshot
Pemetrexed + cisplatin (Pemetrexed + cisplatin) — AstraZeneca. Pemetrexed inhibits multiple folate-dependent enzymes involved in nucleotide synthesis, while cisplatin causes DNA crosslinking; together they disrupt cancer cell division and DNA replication.
Comparator set
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Pemetrexed + cisplatin TARGET | Pemetrexed + cisplatin | AstraZeneca | phase 3 | Antifolate antimetabolite + platinum-based alkylating agent | Thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleotide formyltransferase (pemetrexed); DNA (cisplatin) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Antifolate antimetabolite + platinum-based alkylating agent class)
- AstraZeneca · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Pemetrexed + cisplatin — Competitive Intelligence Brief. https://druglandscape.com/ci/pemetrexed-cisplatin. Accessed 2026-06-10.
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