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Pegylated liposomal doxorubicin hydrochloride — Competitive Intelligence Brief
Target snapshot
Pegylated liposomal doxorubicin hydrochloride (Pegylated liposomal doxorubicin hydrochloride) — M.D. Anderson Cancer Center. Pegylated liposomal doxorubicin delivers the chemotherapy agent doxorubicin encapsulated in liposomes coated with polyethylene glycol, which intercalates into DNA and inhibits topoisomerase II while reducing cardiotoxicity through prolonged circulation and selective tumor accumulation.
Comparator set (6 drugs)
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Pegylated liposomal doxorubicin hydrochloride TARGET | Pegylated liposomal doxorubicin hydrochloride | M.D. Anderson Cancer Center | marketed | Anthracycline chemotherapy (liposomal formulation) | Topoisomerase II, DNA | |
| Cipro | ciprofloxacin | Bayer AG | marketed | Fluoroquinolone antibiotic | DNA topoisomerase II, DNA gyrase subunit A, DNA gyrase subunit A | 1987-10-22 |
| Epirubicin (E) | Epirubicin (E) | Eye & ENT Hospital of Fudan University | marketed | Anthracycline topoisomerase II inhibitor | Topoisomerase II, DNA | |
| Liposomal daunorubicin | Liposomal daunorubicin | University of Birmingham | phase 3 | Anthracycline chemotherapy agent | Topoisomerase II, DNA | |
| epirubicin - cyclophosphamide / docetaxel + bevacizumab | epirubicin - cyclophosphamide / docetaxel + bevacizumab | GBG Forschungs GmbH | phase 3 | anthracycline antibiotic, alkylating agent, taxane, monoclonal antibody | topoisomerase II, DNA, microtubules, VEGF | |
| Daunorubicin or Idarubicin | Daunorubicin or Idarubicin | Stichting Hemato-Oncologie voor Volwassenen Nederland | phase 3 | Anthracycline topoisomerase II inhibitor | Topoisomerase II, DNA | |
| Epirubicin Injectable Product | Epirubicin Injectable Product | The First Affiliated Hospital with Nanjing Medical University | phase 3 | Anthracycline topoisomerase II inhibitor | Topoisomerase II, DNA |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
- — Cipro · 11369566 · Formulation · US
- — Cipro · 9603796 · Compound · US
- — Cipro · 9205048 · Method of Use · US
- — Cipro · 9233068 · Formulation · US
- — Cipro · 8318817 · Method of Use · US
- — Cipro · 9220796 · Formulation · US
- — Cipro · 11040004 · Method of Use · US
- — Cipro · 11246863 · Formulation · US
Sponsor landscape (Anthracycline chemotherapy (liposomal formulation) class)
- M.D. Anderson Cancer Center · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Pegylated liposomal doxorubicin hydrochloride — Competitive Intelligence Brief. https://druglandscape.com/ci/pegylated-liposomal-doxorubicin-hydrochloride. Accessed 2026-05-17.
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