Who are PDE5 inhibitor (tadalafil)'s main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Viagra, Tadalafil versus tamsulosin as MET, Revatio, iv sildenafil, DA-8159 (Udenafil), DA-5212.

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Last reviewed 2026-05-18 · How we verify

PDE5 inhibitor (tadalafil) — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

PDE5 inhibitor (tadalafil) (PDE5 inhibitor (tadalafil)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: PDE5 inhibitor. Area: Oncology.

phase 3 PDE5 inhibitor PDE5 (phosphodiesterase type 5) Oncology Small molecule Live · refreshed every 30 min

Target snapshot

PDE5 inhibitor (tadalafil) (PDE5 inhibitor (tadalafil)) — Regina Elena Cancer Institute. Tadalafil inhibits phosphodiesterase type 5 (PDE5), increasing cyclic GMP levels to promote vasodilation and smooth muscle relaxation.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
PDE5 inhibitor (tadalafil) TARGET	PDE5 inhibitor (tadalafil)	Regina Elena Cancer Institute	phase 3	PDE5 inhibitor	PDE5 (phosphodiesterase type 5)
Viagra	sildenafil	Pfizer Inc.	marketed	PDE5 inhibitor	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, Multidrug resistance-associated protein 5	1998-03-27
Tadalafil versus tamsulosin as MET	Tadalafil versus tamsulosin as MET	Beni-Suef University	marketed	PDE5 inhibitor (tadalafil) vs. alpha-1A adrenergic antagonist (tamsulosin)	PDE5 (tadalafil) vs. alpha-1A adrenergic receptor (tamsulosin)
Revatio	Sildenafil Citrate	Pfizer Inc.	marketed	PDE5 inhibitor	Phosphodiesterase type 5 (PDE5)
iv sildenafil	iv sildenafil	Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	phase 3	PDE5 inhibitor	PDE5
DA-8159 (Udenafil)	DA-8159 (Udenafil)	Dong-A Pharmaceutical Co., Ltd.	phase 3	PDE5 inhibitor	PDE5 (phosphodiesterase type 5)
DA-5212	DA-5212	Dong-A ST Co., Ltd.	phase 3	PDE5 inhibitor	PDE5 (phosphodiesterase 5)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (PDE5 inhibitor class)

Pfizer Inc. · 2 drugs in this class
Dong-A Pharmaceutical Co., Ltd. · 1 drug in this class
Dong-A ST Co., Ltd. · 1 drug in this class
Eli Lilly and Company · 1 drug in this class
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. · 1 drug in this class
Regina Elena Cancer Institute · 1 drug in this class

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Cite this brief

Drug Landscape (2026). PDE5 inhibitor (tadalafil) — Competitive Intelligence Brief. https://druglandscape.com/ci/pde5-inhibitor-tadalafil. Accessed 2026-05-18.

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