Who are p53 with chemotherapy's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): chemotherapy plus p53, rAd-p53 gene, Onasemnogene Abeparvovec-xioi, voretigene neparvovec-rzyl, p53 gene therapy, p53 gene with surgery.

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Last reviewed 2026-05-16 · How we verify

p53 with chemotherapy — Competitive Intelligence Brief

p53 with chemotherapy (p53 with chemotherapy) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Gene therapy; recombinant adenovirus vector. Area: Oncology.

marketed Gene therapy; recombinant adenovirus vector p53 (tumor suppressor protein) Oncology Small molecule Live · refreshed every 30 min

Target snapshot

p53 with chemotherapy (p53 with chemotherapy) — Shenzhen SiBiono GeneTech Co.,Ltd. A gene therapy that delivers functional p53 tumor suppressor gene to cancer cells to restore apoptosis and cell cycle arrest, used in combination with chemotherapy.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
p53 with chemotherapy TARGET	p53 with chemotherapy	Shenzhen SiBiono GeneTech Co.,Ltd	marketed	Gene therapy; recombinant adenovirus vector	p53 (tumor suppressor protein)
chemotherapy plus p53	chemotherapy plus p53	Shenzhen SiBiono GeneTech Co.,Ltd	marketed	Combination chemotherapy with p53 gene therapy	p53 tumor suppressor protein
rAd-p53 gene	rAd-p53 gene	Shenzhen SiBiono GeneTech Co.,Ltd	marketed	Gene therapy; oncolytic virus	p53 tumor suppressor gene
Onasemnogene Abeparvovec-xioi	Onasemnogene Abeparvovec-xioi	Novartis Gene Therapies	marketed	Gene therapy	SMN1 gene
voretigene neparvovec-rzyl	voretigene neparvovec-rzyl	Spark Therapeutics, Inc.	marketed	Gene therapy	RPE65 gene
p53 gene therapy	p53 gene therapy	Shenzhen SiBiono GeneTech Co.,Ltd	marketed	Gene therapy	p53 (tumor suppressor protein)
p53 gene with surgery	p53 gene with surgery	Shenzhen SiBiono GeneTech Co.,Ltd	marketed	Gene therapy (p53 tumor suppressor)	p53 (tumor protein p53)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Gene therapy; recombinant adenovirus vector class)

Shenzhen SiBiono GeneTech Co.,Ltd · 1 drug in this class

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Cite this brief

Drug Landscape (2026). p53 with chemotherapy — Competitive Intelligence Brief. https://druglandscape.com/ci/p53-with-chemotherapy. Accessed 2026-05-16.

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