Who are Oral palonosetron's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Trintellix, Zofran inj.+Zofran tab., fosnetupitant/ palonosetron, Ondansetron orodispersible film once, Aprepitant plus Ondansetron, ondansetron (Zofran).

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Last reviewed 2026-05-16 · How we verify

Oral palonosetron — Competitive Intelligence Brief

Oral palonosetron (Oral palonosetron) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: 5-HT3 receptor antagonist. Area: Oncology.

phase 3 5-HT3 receptor antagonist 5-HT3 receptor Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Oral palonosetron (Oral palonosetron) — Helsinn Healthcare SA. Palonosetron works by blocking serotonin 5-HT3 receptors in the body, which helps to prevent nausea and vomiting.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Oral palonosetron TARGET	Oral palonosetron	Helsinn Healthcare SA	phase 3	5-HT3 receptor antagonist	5-HT3 receptor
Trintellix	vortioxetine	Takeda	marketed	Serotonin modulator and stimulator (SMS); SSRI-like agent	Serotonin transporter (SERT); 5-HT3 receptor; 5-HT1A receptor	2013-01-01
Zofran inj.+Zofran tab.	Zofran inj.+Zofran tab.	LG Life Sciences	marketed	5-HT3 receptor antagonist	5-HT3 receptor
fosnetupitant/ palonosetron	fosnetupitant/ palonosetron	Helsinn Healthcare SA	marketed	NK1 receptor antagonist / 5-HT3 receptor antagonist combination	NK1 receptor (substance P receptor) / 5-HT3 receptor
Ondansetron orodispersible film once	Ondansetron orodispersible film once	Chongqing University Cancer Hospital	marketed	5-HT3 receptor antagonist	5-HT3 receptor
Aprepitant plus Ondansetron	Aprepitant plus Ondansetron	University of Pittsburgh	marketed	NK1 receptor antagonist + 5-HT3 receptor antagonist combination	NK1 receptor (aprepitant); 5-HT3 receptor (ondansetron)
ondansetron (Zofran)	ondansetron (Zofran)	National Institute on Alcohol Abuse and Alcoholism (NIAAA)	marketed	5-HT3 receptor antagonist	5-HT3 receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (5-HT3 receptor antagonist class)

Helsinn Healthcare SA · 4 drugs in this class
LG Life Sciences · 3 drugs in this class
University of Malaya · 2 drugs in this class
GlaxoSmithKline · 1 drug in this class
Hamad Medical Corporation · 1 drug in this class
Eye & ENT Hospital of Fudan University · 1 drug in this class
Instituto Mexicano del Seguro Social · 1 drug in this class
Chongqing University Cancer Hospital · 1 drug in this class
Merck Sharp & Dohme LLC · 1 drug in this class
MonoSol Rx · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Oral palonosetron — Competitive Intelligence Brief. https://druglandscape.com/ci/oral-palonosetron. Accessed 2026-05-16.

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