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Oral Capecitabine with Irinotecan — Competitive Intelligence Brief
phase 3
Antimetabolite and topoisomerase I inhibitor combination
Thymidylate synthase (via 5-FU); Topoisomerase I
Oncology
Small molecule
Live · refreshed every 30 min
Target snapshot
Oral Capecitabine with Irinotecan (Oral Capecitabine with Irinotecan) — Pfizer. Capecitabine is converted to 5-fluorouracil to inhibit thymidylate synthase and disrupt DNA synthesis, while irinotecan inhibits topoisomerase I to prevent DNA unwinding during replication, together producing synergistic cytotoxic effects against cancer cells.
Comparator set
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Oral Capecitabine with Irinotecan TARGET | Oral Capecitabine with Irinotecan | Pfizer | phase 3 | Antimetabolite and topoisomerase I inhibitor combination | Thymidylate synthase (via 5-FU); Topoisomerase I |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Antimetabolite and topoisomerase I inhibitor combination class)
- Pfizer · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Oral Capecitabine with Irinotecan — Competitive Intelligence Brief. https://druglandscape.com/ci/oral-capecitabine-with-irinotecan. Accessed 2026-05-16.
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