Who are OPC-41061's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Samsca, Physulime, Vaprisol In 5% Dextrose In Plastic Container, tolvaptan+torasemide, Tolvaptan or Samsca, OPC-41061 （Tolvaptan).

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Last reviewed 2026-06-09 · How we verify

OPC-41061 — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

OPC-41061 (OPC-41061) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Vasopressin V2 receptor antagonist (vaptан). Area: Cardiovascular / Nephrology.

phase 3 Vasopressin V2 receptor antagonist (vaptан) Vasopressin V2 receptor Cardiovascular / Nephrology Small molecule Live · refreshed every 30 min

Target snapshot

OPC-41061 (OPC-41061) — Otsuka Pharmaceutical Co., Ltd.. OPC-41061 is a vasopressin V2 receptor antagonist (vaptан) that blocks water reabsorption in the kidney collecting duct, promoting aquaresis and increasing serum sodium levels.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
OPC-41061 TARGET	OPC-41061	Otsuka Pharmaceutical Co., Ltd.	phase 3	Vasopressin V2 receptor antagonist (vaptан)	Vasopressin V2 receptor
Samsca	TOLVAPTAN	Otsuka	marketed	Vasopressin V2 Receptor Antagonist [EPC]	Vasopressin V2 receptor	2009-01-01
Physulime	MOZAVAPTAN	Otsuka Pharmaceutical Co., Ltd.	marketed	mozavaptan	Vasopressin V2 receptor	2006-01-01
Vaprisol In 5% Dextrose In Plastic Container	CONIVAPTAN	Cumberland	marketed	Vasopressin Receptor Antagonist	Vasopressin V2 receptor	2005-01-01
tolvaptan+torasemide	tolvaptan+torasemide	Shanghai Chest Hospital	marketed	Combination diuretic (vasopressin V2 receptor antagonist + loop diuretic)	Vasopressin V2 receptor (tolvaptan); Na-K-Cl cotransporter (torasemide)
Tolvaptan or Samsca	Tolvaptan or Samsca	Cardiovascular Clinical Sciences Inc	phase 3	Vasopressin V2 receptor antagonist	Vasopressin V2 receptor
OPC-41061 （Tolvaptan)	OPC-41061 （Tolvaptan)	Otsuka Pharmaceutical Co., Ltd.	phase 3	Vasopressin V2 receptor antagonist	Vasopressin V2 receptor

Recent regulatory actions (last 90 days)

2026-04-21 — OPC-41061 · FDA · approved · US · Otsuka Pharmaceutical Co., Ltd.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Vasopressin V2 receptor antagonist (vaptан) class)

Otsuka Pharmaceutical Co., Ltd. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). OPC-41061 — Competitive Intelligence Brief. https://druglandscape.com/ci/opc-41061. Accessed 2026-06-09.

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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing