Who are Onasemnogene Abeparvovec-brve's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Onasemnogene Abeparvovec-xioi, rAd-p53 gene, chemotherapy plus p53, voretigene neparvovec-rzyl, p53 gene with surgery, p53 with chemotherapy.

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Last reviewed 2026-05-17 · How we verify

Onasemnogene Abeparvovec-brve — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Onasemnogene Abeparvovec-brve (Onasemnogene Abeparvovec-brve) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Gene Therapy. Area: Neuroscience.

marketed Gene Therapy SMN1 gene Neuroscience Small molecule Live · refreshed every 30 min

Target snapshot

Onasemnogene Abeparvovec-brve (Onasemnogene Abeparvovec-brve) — Novartis Pharmaceuticals. ITVISMA delivers a functional SMN1 gene using an AAV9 vector to promote SMN protein expression in motor neurons.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Onasemnogene Abeparvovec-brve TARGET	Onasemnogene Abeparvovec-brve	Novartis Pharmaceuticals	marketed	Gene Therapy	SMN1 gene
Onasemnogene Abeparvovec-xioi	Onasemnogene Abeparvovec-xioi	Novartis Gene Therapies	marketed	Gene therapy	SMN1 gene
rAd-p53 gene	rAd-p53 gene	Shenzhen SiBiono GeneTech Co.,Ltd	marketed	Gene therapy; oncolytic virus	p53 tumor suppressor gene
chemotherapy plus p53	chemotherapy plus p53	Shenzhen SiBiono GeneTech Co.,Ltd	marketed	Combination chemotherapy with p53 gene therapy	p53 tumor suppressor protein
voretigene neparvovec-rzyl	voretigene neparvovec-rzyl	Spark Therapeutics, Inc.	marketed	Gene therapy	RPE65 gene
p53 gene with surgery	p53 gene with surgery	Shenzhen SiBiono GeneTech Co.,Ltd	marketed	Gene therapy (p53 tumor suppressor)	p53 (tumor protein p53)
p53 with chemotherapy	p53 with chemotherapy	Shenzhen SiBiono GeneTech Co.,Ltd	marketed	Gene therapy; recombinant adenovirus vector	p53 (tumor suppressor protein)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Gene Therapy class)

Novartis Pharmaceuticals · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Onasemnogene Abeparvovec-brve — Competitive Intelligence Brief. https://druglandscape.com/ci/onasemnogene-abeparvovec-brve. Accessed 2026-05-17.

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