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Olanzapine+NK-1 RA+5-HT3 RA — Competitive Intelligence Brief
phase 3
Combination antipsychotic + antiemetic
Dopamine D2, serotonin 5-HT2A (olanzapine); Substance P/NK-1 receptor (NK-1 RA); 5-HT3 receptor (5-HT3 RA)
Oncology (supportive care) / Psychiatry
Small molecule
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Target snapshot
Olanzapine+NK-1 RA+5-HT3 RA (Olanzapine+NK-1 RA+5-HT3 RA) — Fifth Affiliated Hospital, Sun Yat-Sen University. This combination blocks dopamine/serotonin (olanzapine), substance P signaling (NK-1 RA), and serotonin 5-HT3 receptors to reduce nausea, vomiting, and potentially improve psychiatric symptoms.
Comparator set
| Drug | Generic | Sponsor | Phase | Class | Target | Approval / PDUFA |
|---|---|---|---|---|---|---|
| Olanzapine+NK-1 RA+5-HT3 RA TARGET | Olanzapine+NK-1 RA+5-HT3 RA | Fifth Affiliated Hospital, Sun Yat-Sen University | phase 3 | Combination antipsychotic + antiemetic | Dopamine D2, serotonin 5-HT2A (olanzapine); Substance P/NK-1 receptor (NK-1 RA); 5-HT3 receptor (5-HT3 RA) |
Recent regulatory actions (last 90 days)
Upcoming PDUFA dates (next 180 days)
Patent timeline (forward window)
Sponsor landscape (Combination antipsychotic + antiemetic class)
- Fifth Affiliated Hospital, Sun Yat-Sen University · 1 drug in this class
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Cite this brief
Drug Landscape (2026). Olanzapine+NK-1 RA+5-HT3 RA — Competitive Intelligence Brief. https://druglandscape.com/ci/olanzapine-nk-1-ra-5-ht3-ra. Accessed 2026-05-18.
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