Who are NMRA-335140's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Latuda©, Latuda (Lurasidone), NRX-101 Oral Capsule, Vortioxetine (Lu AA21004), OPC-34712, Lu AA21004.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-13 · How we verify

NMRA-335140 — Competitive Intelligence Brief

NMRA-335140 (NMRA-335140) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: 5-HT7 receptor antagonist. Area: Psychiatry/Neurology.

phase 3 5-HT7 receptor antagonist 5-HT7 receptor Psychiatry/Neurology Small molecule Live · refreshed every 30 min

Target snapshot

NMRA-335140 (NMRA-335140) — Neumora Therapeutics, Inc.. NMRA-335140 is a selective serotonin 5-HT7 receptor antagonist designed to modulate mood and emotional processing through central nervous system effects.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
NMRA-335140 TARGET	NMRA-335140	Neumora Therapeutics, Inc.	phase 3	5-HT7 receptor antagonist	5-HT7 receptor
Latuda©	Latuda©	University of North Carolina, Chapel Hill	marketed	Atypical antipsychotic	Dopamine D2 receptor, serotonin 5-HT7 receptor, serotonin 5-HT1A receptor
Latuda (Lurasidone)	Latuda (Lurasidone)	Massachusetts General Hospital	marketed	Atypical antipsychotic	Dopamine D2 receptor, Serotonin 5-HT7 receptor
NRX-101 Oral Capsule	NRX-101 Oral Capsule	NeuroRx, Inc.	phase 3	Fixed-dose combination (NMDA receptor modulator + atypical antipsychotic)	NMDA receptor (d-cycloserine component); dopamine D2 receptor and serotonin 5-HT7 receptor (lurasidone component)
Vortioxetine (Lu AA21004)	Vortioxetine (Lu AA21004)	H. Lundbeck A/S	phase 3	Serotonin modulator and stimulator	5-HT3 receptor, 5-HT1A receptor, 5-HT7 receptor, norepinephrine transporter
OPC-34712	OPC-34712	Otsuka Pharmaceutical Development & Commercialization, Inc.	phase 3	5-HT7 receptor antagonist	5-HT7 receptor
Lu AA21004	Lu AA21004	H. Lundbeck A/S	phase 3	Multimodal antidepressant; serotonin reuptake inhibitor with 5-HT1A agonist and 5-HT7 antagonist activity	Serotonin transporter (SERT), 5-HT1A receptor, 5-HT7 receptor

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (5-HT7 receptor antagonist class)

Otsuka Pharmaceutical Development & Commercialization, Inc. · 2 drugs in this class
Dr. Reddy's Laboratories Limited · 1 drug in this class
Eli Lilly and Company · 1 drug in this class
Neumora Therapeutics, Inc. · 1 drug in this class

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Cite this brief

Drug Landscape (2026). NMRA-335140 — Competitive Intelligence Brief. https://druglandscape.com/ci/nmra-335140. Accessed 2026-05-13.

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