Who are Nivolumab in combination with Ipilimumab's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): APVO101, AK102, Neoadjuvant ipilimumab + nivolumab, Adjuvant Nivolumab and Ipilimumab, Nivolumab & Ipilimumab.

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Last reviewed 2026-05-17 · How we verify

Nivolumab in combination with Ipilimumab — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Nivolumab in combination with Ipilimumab (Nivolumab in combination with Ipilimumab) competitive landscape: 5 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Checkpoint inhibitor combination (PD-1 inhibitor + CTLA-4 inhibitor). Area: Oncology.

marketed Checkpoint inhibitor combination (PD-1 inhibitor + CTLA-4 inhibitor) PD-1 and CTLA-4 Oncology Small molecule Live · refreshed every 30 min

Target snapshot

Nivolumab in combination with Ipilimumab (Nivolumab in combination with Ipilimumab) — Bristol-Myers Squibb. Nivolumab and ipilimumab together block two different immune checkpoints (PD-1 and CTLA-4) to enhance anti-tumor immune responses.

Comparator set (5 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Nivolumab in combination with Ipilimumab TARGET	Nivolumab in combination with Ipilimumab	Bristol-Myers Squibb	marketed	Checkpoint inhibitor combination (PD-1 inhibitor + CTLA-4 inhibitor)	PD-1 and CTLA-4
APVO101	APVO101	Medexus Pharma, Inc.	phase 3	Dual checkpoint inhibitor	PD-1 and CTLA-4
AK102	AK102	Akeso	phase 3	Bispecific checkpoint inhibitor	PD-1 and CTLA-4
Neoadjuvant ipilimumab + nivolumab	Neoadjuvant ipilimumab + nivolumab	The Netherlands Cancer Institute	phase 3	Immune checkpoint inhibitor combination	PD-1 and CTLA-4
Adjuvant Nivolumab and Ipilimumab	Adjuvant Nivolumab and Ipilimumab	Universitätsklinikum Hamburg-Eppendorf	phase 3	PD-1 inhibitor and CTLA-4 inhibitor combination	PD-1 and CTLA-4
Nivolumab & Ipilimumab	Nivolumab & Ipilimumab	The First Affiliated Hospital of Guangzhou Medical University	phase 3	PD-1 inhibitor + CTLA-4 inhibitor combination	PD-1 and CTLA-4

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Checkpoint inhibitor combination (PD-1 inhibitor + CTLA-4 inhibitor) class)

Bristol-Myers Squibb · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Nivolumab in combination with Ipilimumab — Competitive Intelligence Brief. https://druglandscape.com/ci/nivolumab-in-combination-with-ipilimumab. Accessed 2026-05-17.

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